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Prognosis and diagnostics in acute myeloid leukemia
Jiráková Trnková, Zuzana ; Jíra, Milan (advisor) ; Černá, Marie (referee) ; Špíšek, Radek (referee)
The main aim of the dissertation was in patients with acute myeloid leukemia to investigate the impact of favorable prognostic chromosomal aberrations and increased expression of a family of multiple drug resistance genes to achieve a complete remission and overall survival, and identify the potential prognostic factors. Experiments were focused on the introduction of routine diagnostics of two prognostically favorable fusion genes, AML1/ETO and CBFbeta/MYH11 and multiple drug resistance gene MDR1. This testing was performed by reverse transcription, PCR and subsequent electrophoretic analysis of its products.
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Do family policies really affect fertility levels?
Jiráková, Zuzana ; Pertold-Gebicka, Barbara (advisor) ; Votápková, Jana (referee)
One of the main objectives of family policies in countries with low fertility levels is to stimulate birth rates and incentivize the citizens to have more children. Nevertheless, the research on whether this objective is being met remains inconclusive. In this thesis, we analyze two reforms which took place in the Czech Republic in 1995 and 2008, which adjusted the period of reception of the parental allowance. We use data from selected European OECD countries along with the synthetic control approach to construct a synthetic counterpart to the Czech Republic which gives us an idea about how fertility levels would have developed if the interventions did not take place. In both cases, 1995 reform and 2008 reform, we do not find any conclusive evidence that the interventions affected fertility levels in the Czech Republic. Moreover, we observe a change in the trend of total fertility rate about 2 years before each reform which suggests that these reforms were more likely reactions to changing fertility rates rather than remedies. JEL Classification J13, J17, J11, J12, E61, E65, F68 Keywords fertility, family policy, synthetic control estimator, parental allowance, parental leave Author's e-mail 31609261@fsv.cuni.cz Supervisor's e-mail barbara.pertold-gebicka@fsv.cuni.cz
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The Impact of Switching Costs on the Customer Satisfaction-Loyalty Link: Mobile Phone Service in the Czech Republic
Jiráková, Zuzana ; Polák, Petr (advisor) ; Doležel, Pavel (referee)
This thesis seeks to explain the dynamics influencing customer loyalty in the Czech market for mobile phone services. Customer loyalty is an important concept in such a saturated market where acquisition of new customers nearly always merits convincing them to leave their current provider, so customer retention is a more adequate strategy to ensure business prosperity. Structural equation modeling is employed in order to build a reliable model which would explain the relationships among the concepts of customer satisfaction, customer loyalty, service quality, and the role of switching costs. The results yield supporting evidence for the positive relationship between service quality and customer satisfaction, as well as the positive relationship between customer satisfaction and customer loyalty. There is no conclusive evidence for the impact of switching costs on the satisfaction-loyalty link.
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Prognosis and diagnostics in acute myeloid leukemia
Jiráková Trnková, Zuzana ; Jíra, Milan (advisor) ; Černá, Marie (referee) ; Špíšek, Radek (referee)
The main aim of the dissertation was in patients with acute myeloid leukemia to investigate the impact of favorable prognostic chromosomal aberrations and increased expression of a family of multiple drug resistance genes to achieve a complete remission and overall survival, and identify the potential prognostic factors. Experiments were focused on the introduction of routine diagnostics of two prognostically favorable fusion genes, AML1/ETO and CBFbeta/MYH11 and multiple drug resistance gene MDR1. This testing was performed by reverse transcription, PCR and subsequent electrophoretic analysis of its products.
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