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Národní úložiště šedé literatury Nalezeno 2 záznamů.  Hledání trvalo 0.00 vteřin. 
Combination of cobalt bis(dicarbollide) amino derivative and antibiotic effect on growth of staphylococcus epidermidis
 Lokočová, K. ; Vaňková, E. ; Šícha, Václav ; Masák, J.
Nosocomial infections are often caused by bacteria from the Staphylococcus genus. The clinically relevant representatives of this species are Staphylococcus epidermidis and Staphylococcus aureus which grow predominantly as surface-attached stable communities known as biofilms. Cells in these biofilms are often highly resistant to antibiotics. Therefore, new antimicrobial or antibiofilm substances are still being developed. In this study, we investigated the influence of cobalt bis(dicarbollide) or its amino derivatives, and antibiotics (erythromycin, tetracycline)-alone and in combination-to determine the antimicrobial activity and the inhibition of biofilm formation against three type strains of S. epidermidis. We used a microcultivation device to determine the minimum inhibitory concentrations and MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay to determine the metabolic activity of the cells in biofilms. We observed the synergistic effect of cobalt bis(dicarbollide) and its amino derivatives with both the antibiotics on both the planktonic and biofilm cells.
Úplný záznam
Antimicrobial activity of cobalt bis(dicarbollide) aminoderivatives
 Kvasničková, E. ; Masák, J. ; Šícha, Václav
We carried out experiments focused on the determination of the antimicrobial acitivity of selected representatives of cobalt bis{dicarbollide) aminoderivates. lt was proved, that studied yeast strain C. parapsilosis DBM 2165 is not sensitive to the cobalt bis{dicarbollide) or its aminoderivatives. Gram-negative bacteria P. aeruginosa B-59188 is weakly susceptive to cobalt bis(dicarbollide), but no significant inhibition of growth by cobalt bis(dicarbollide) aminoderivatives was observed. The highest effect on inhibition of microbial growth was confirmed in the case of gram-positive bacteria 5. aureus. This observation demonstrates the real possibility of using these substances in the treatment of infection caused by gram-positive bacterial strains.
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