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Establishing Mutual Links among Brain Structures
Klimeš, Petr ; Hlinka,, Jaroslav (referee) ; Krajča,, Vladimír (referee) ; Halámek, Josef (advisor)
The Human brain consists of mutually connected neuronal populations that build anatomically and functionally separated structures. To understand human brain activity and connectivity, it is crucial to describe how these structures are connected and how information is spread. Commonly used methods often work with data from scalp EEG, with a limited number of contacts, and are incapable of observing dynamic changes during cognitive processes or different behavioural states. In addition, connectivity studies almost never analyse pathological parts of the brain, which can have a crucial impact on pathology research and treatment. The aim of this work is connectivity analysis and its evolution in time during cognitive tasks using data from intracranial EEG. Physiological processes in cognitive stimulation and the local connectivity of pathology in the epileptic brain during wake and sleep were analysed. The results provide new insight into human brain physiology research. This was achieved by an innovative approach which combines connectivity methods with EEG spectral power calculation. The second part of this work focuses on seizure onset zone (SOZ) connectivity in the epileptic brain. The results describe the functional isolation of the SOZ from the surrounding tissue, which may contribute to clinical research and epilepsy treatment.
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City House – Mixet Use Architecture
Veselá, Jana ; Urbášková,, Hana (referee) ; Menšíková, Naděžda (advisor)
The territory lies in the City of Brno, in the urban district of Zábrdovice. From the east it is demarcated by the Svitava River, from the south by the Cejl Street, and from the west by the Jan Svoboda Street. Its area is approximately 18,790 m2. From the standpoint of urban planning¸ the intensive house is a separate city block, which is, nevertheless, open in the eastern direction towards the Svitava River, thus communicating with the embankment. In the other direction there is both private and semi-private space inside the block as a relaxation green “garden” in several levels. The mass of the object links up in the prolonged line with the existing neighbouring blocks and thus respects the integrity of the territory. Intensive use of the territory consists in the achievement of high density of built-up area, and at the same time preserving the surroundings of quality for life and habitation. Functions are mixed here and a city of short distances is created here with nearly excluded traffic. In order to achieve such intensity, space urbanism is employed. The principle consists in a simple linear form of masses respecting the shape of the lot, which is vivified with an ellipsoid located in the courtyard, which is an accent towards the linear form. The ellipsoid serves as a small cultural and exhibition centre, at the same time connecting all the arms of the defining block and bringing daylight to the first floor. The block is open in the direction to the river and its half-public space is connected with the embankment with a staircase and verdure. Verdure is also made use of on the roofs. The defining mass is perforated, thus creating covered terraces. The principal architectonic intention was to create an integrated structure, where a significant role is played by the introduction of nature and polyfunctionality to the whole territory, thus increasing its attractivity. From the dispositional perspective the individual functions interpenetrate at al
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Software for patients and brain regions selection suitable for analysis of connectivity in fMRI
Slavíček, Tomáš ; Lamoš, Martin (referee) ; Jan, Jiří (advisor)
The aim of this thesis is to create an exploratory tool for functional magnetic resonance imaging data, which allows quickly and easily making a selection of persons and areas suitable for group analysis of connectivity. In the first chapters of this work is mentioned history of brain research and comparison of methods used in functional imaging. Next they are discussed the theoretical basis of fMRI methods, such as the formation of BOLD signal, acquisition parameters of MRI images and methods for designing experiments. The following chapter describes in detail the analysis of recorded data from the pre-processing to the interpretation of results. The last chapter of the first part describes problems of group analysis in SPM8 software. The second half of this work is dedicated to the description of developed program from data input to saving the results, including detailed descriptions of key features. In conclusion, there is a chapter characterizing the application of developed program on real data from clinical studies, including the results and evaluation of the usability of program. The program will mainly be used in neuroscience research.
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