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Antiviral vaccination - hepatitis A virus
Rančáková, Hana ; Fraiberk, Martin (referee) ; Drda Morávková, Alena (advisor)
Hepatitis A is an ifectious disease caused by Hepatitis A virus (HAV) from Picornaviridae family. HAV is an uneveloped virus composed of positive single-stranded RNA and a capsid with icosahedral symmetry. This infection is wide-spread and endemic in many regions of the world. The main way of transmission is throught the fecal-oral route. The possible symptoms, that can appear during the disease are fever, fatigue, muscle-pain, nausea, vomiting and afterward yellowish discoloration of the skin and mucous membranes. On the other hand, the disease can proceed without any symptoms, that is common especially in the childhood. The people can shelter from the disease by aplication of vaccine. At this time there are four inactivated hepatitis A vaccines at the world market. All of the vaccines are highly effective and provide a long-term protection. This work is intent on the infection of hepatitis A virus, the possibilities of prevention with vaccines and the inclusion of curriculum about viral diseases and vaccination in the School Educational Programmes.
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Ebola as a medical and social problem
Gantsetseg, Purevsuren ; Hladká, Petra (advisor) ; Kordulová, Pavla (referee)
Introduction: The aim of bachelor thesis is about the preparedness of health care facilities. The unexpected epidemic of Ebola 2014 in West Africa has become an international concern and the preparedness of health care facilities, prevention and control of this disease have become a major issue of concern. Methodology: For the development of the thesis, we chose a qualitative method, a form of research was an interview. The questions were designed in our own creation. The interview was conducted by epidemiological workers in surveyed health care facilities. The main objective of the research was to determine, what the methodologies in health care facilities are during admission and stay of a patient with Ebola. Results: From our analysis, the survey indicates that the organizational structure of hospital care ensures that patient with Ebola are handled according to the Government decree no. 15/2013 and health care facilities proceed according to the directive for unified procedure. In the development of an extraordinary incident, this is subjected to the International Health regulations in relation to the occurrence of highly dangerous infectious diseases in a health care facility. Another finding is that health professionals are familiar with the procedures in care of an Ebola patient by developed...
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The question of mandatory vaccination and vaccination coverage
Borovcová, Anna ; Bezchlebová, Daniela (advisor) ; Fabiánová, Jana (referee)
The main concern of this thesis is the issue of mandatory vaccination and vaccination coverage in the Czech Republic. Therefore it focuses on all vaccines against infectious diseases which are now mandatory for all of the children: measles, mumps, rubella, diphtheria, tetanus, viral hepatitis B, poliomyelitis and diseases caused by Haemophilus influenzae type b. The goal of this thesis is to illustrate the importance and benefits of vaccination on incidence and mortality of these diseases. Another part of this thesis is also description of methodology which is used to gather data about vaccination coverage and what the results are. In this part Liberec Region is used as an example. As a result of the unsuitable methodology which is used for data gathering in the Czech Republic, it was not possible to say whether the vaccination coverage de-creases in time. The thesis itself provides an information overview about vaccination which is important from demographic point of view and it also might be an impulse for changing current methodology of data collection.
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Types and frequency of infectious diseases in the Pilsen region in a sample of extraordinary events
BLABOLOVÁ, Jana
The bachelor thesis deals with structure and frequency of infectious diseases in the Pilsen region in a sample of emergency. The selected sample represents the basic components of integrated rescue system. Introduction describes each part of this work, aims and ways how to meet objectives of this work. Theoretical part focuses on current development of the whole issue and legislation governing the issue of infectious diseases and measures against them in the Pilsen Region. Theoretical part provides a breakdown of a territory with regard to the basin, description of integrated rescue system in terms of Pilsen Region and general aspects, including basic legal rules governing the various components of integrated rescue system and emergency response. This section also describes general infectious diseases, dissemination, transmission of infectious agents, forms of occurrence, symptoms and forms of course. From extraordinary events, where dominates a risk of infectious diseases, with possibility of significant increase of diseases in the sample, I chose floods (flood). The most infectious diseases I chose for my work were leptospirosis, dysentery, viral hepatitis A and tularemia, as these kinds of infectious diseases have been identified as threatening to flood. Selected species of infectious diseases have been in this part of the work elaborated. They also described their occurrence, the risk that these pose to members of the basic components of the integrated rescue system and possible preventive measures to minimize the risk of their occurrence. The research part of this thesis deals with hypotheses and methodology of work. To meet the objectives of the work and test hypotheses, I used structured anonymous questionnaire. The target group of respondents of the questionnaire consisted of members of basic components of integrated rescue system in the Pilsen region - from the Police of the Czech Republic included in the district departments, members of the Fire and Rescue Service of the Czech Republic assigned to fire stations and emergency medical service members stationed at ambulance stations. The aim of the study was to determine the potential increase of selected infectious diseases in basic components of integrated rescue system during certain types of emergencies and at some time after them in Pilsen region, to identify the most common types of infectious diseases and to determine the level of the Base of the Integrated Rescue System on these selected infectious diseases. There were contained 26 questions in the questionnaire. Questions were directed to identify any increase of selected infectious disease emergency and at some time after them in the Pilsen region, information on basic components of the integrated rescue system and to identify the most common infectious diseases in the context of the extraordinary events in the Pilsen Region. The results of this survey and discussion of the assumptions of work: among members of basic components of the Integrated Rescue System an increase of selected infectious diseases in connection with the incident and informed members of the Integrated Rescue System on selected infectious diseases is sufficient, there was found that members of basic components of the Integrated Rescue system, there was no increase of selected infectious diseases in connection with the incident and informed members of basic components of the integrated rescue system on selected infectious diseases is sufficient. Both hypotheses are related, because awareness is also part of the principles of hygiene, use of protective equipment and thus minimize the risk of infectious diseases. The results also showed that only one respondent ill selected infectious diseases, but not in connection with an incident. The lowest percentage of correct answers of the characteristics of selected infectious diseases was with leptospirosis.
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Analysis of Occurrence of Imported Infectious Diseases in the Region of South Bohemia over the Last Five Years
MYSLÍK, Ladislav
Imported diseases are infections that have been acquired during a travel or a stay abroad. Such infectious diseases may include cosmopolitan and potential re-introduction illnesses and tropical and re-emerging illnesses. The movement of populations affects the distribution and spread of communicable diseases globally. Today?s mobility and unnatural interaction of different races or otherwise geographically defined populations facilitate the emergence of contagious diseases in humans, animals or, even in plants. Some pathogens can be imported into a new area by travellers or immigrants in the absence of illness signs or symptoms. Many geographical barriers have now been breached by mobility and migration. The theoretical section of this thesis is mainly aimed to provide a description of the most common imported diseases according to their current epidemiological trends. Travel-related risks, risk groups of travellers and migration characteristics are also mentioned. In addition, it deals with domestic and international inbound and outbound tourism and includes a forecast of international tourism development towards 2030. The conclusion of the theoretical section aims to describe epidemiology of imported diseases and to provide an insight into systems of monitoring and surveillance of travel-related infections, such as GeoSentinel Surveillance Network, EuroTravNet, TropNet and the Czech Nationwide Epidat information system. The objective of this diploma thesis of the empirical section is to carry out an analysis of occurrence of imported infectious diseases in the Region of South Bohemia over the last five years. Data and information recorded into Epidat database from 2007 to 2011 shapes the target group. Methods of research are mainly based on descriptive statistics that describe most of collected data quantitatively. Moreover, seven hypotheses were designed that were tested via results using regression analysis, Pearson's chi-squared test and Student's t-test. A total of 190 cases from 46 world-wide destinations were imported between 2007 and 2011. Of those, 166 were imported by residents; 24 cases were brought in by foreigners. The most frequent countries of acquisition were European destinations (49%; n = 92), Asia (33%; n = 63) and Africa (16%; n = 31). Gastro-intestinal (GI) diseases accounted for 68.4% of illnesses, followed by blood-borne and vector-borne infections. GI conditions included campylobacteriosis (n = 38), salmonellosis (n = 33) and shigellosis (n = 30). Amongst blood-borne diseases, hepatitis B accounted for 21 cases (mainly in Vietnamese). Amongst vector-borne illnesses, 6 cases of malaria and 1 case of dengue were identified. Hypothesis H1 (further described only as H2, etcetera) "There is an association between numbers of travellers and occurrence of imported infectious diseases" was rejected. H2 "There is a different incidence rate among countries of acquisition" could not be confirmed because of the lack of the denominator data (numbers of travellers to specific destinations). H3 "The most frequent countries of acquisition are European countries" was confirmed and accepted. H4 "The highest rate of imported infectious diseases is in the České Budějovice District" was confirmed and accepted. H5 "The most frequent imported infections are gastro-intestinal diseases" was confirmed and accepted. H6 "There is a descending tendency of occurrence of imported infectious diseases" was rejected. H7 "There is a higher likelihood of presenting with a vaccination preventable disease in unvaccinated returned travellers" could not be confirmed due to the lack of data.
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Population´s Awareness in Case of Epidemic Infection Herd Occurrence
SÝKOROVÁ, Žaneta
Population´s Awareness in Case of Epidemic Infection Herd Occurrence This diploma work deals with the problem of biological weapons. It consists of a theoretical and a practical part. The theoretical part describes biological weapons in general, the options of their use and the principles of population´s protection. Further, I focussed on selected diseases which are considered to present biological weapons. The information I acquired is based on technical literature, the internet and the current legislation. The practical part of my diploma work deals with the opinions and attitudes of the Czech population concerning biological weapons and the potential risks of being exposed to biological weapons. Further I tried to find out whether the Czech population is aware of the basic issues of the problem in question. At the same time I focussed on comparing the state of awareness in the age groups of the economically active population on the one side and senior citizens on the other side. The research results have shown that the issue of biological weapons tends not to be appreciated adequately and that the opinions found in both age groups do not show significant differences. Further, an analysis of the acquired data has shown that the rate of awareness of the basic issues of the problem is low and that the population lacks sufficient information how to respond to a biological weapon attack in case of suspected assault. Differences in the level of awareness in the studied age groups have not been confirmed. The research has also shown that the respondents feel they do not have access to sources of sufficient and adequate information on biological weapons. Based on the acquired facts I have written a brochure providing information on biological weapons as well as on the recommended measures in case of suspected exposure. I have also elaborated a proposal concerning the implementation of the project and the distribution of the brochure.
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Incidence of Blood-Born and Sexually Transmitted Infectious Diseases with Focus on HBV and HCV in the Central Bohemia Region.
VELEKOVÁ, Petra
Viral hepatitides B and C are among the most widespread and at the same time most serious blood-born and sexually transmitted infectious diseases. The World Health Organisation considers the incidence of both infections to be an epidemic and, according to its estimates, there are 2 billion of people infected by hepatitis B virus and over 170 million of people infected by hepatitis C virus worldwide. Viral hepatitides B and C are diseases infecting the liver frequently becoming chronic and presenting a major factor in hepatocellular carcinoma development. Acute hepatitis C allegedly develops into chronic condition in approximately 85 % of CASE, and around one third of chronic hepatitis C patiens develop cirrhosis and many of them a liver carcinoma. There is a direct correlation between the incidence of acute hepatitis B developing into a chronic condition and possibly leading to cirrhosis or a hepatocellular carcinoma and the patientś age, it is indicated at 90 {--} 95 % in neonates, at 25 {--} 50 % in 1 to 5-year-olds, at 5 {--} 10 % in older children and adults. These diseases also have considerable socioeconomic impacts. Vaccination has been the most effective preventive measure agains viral hepatitis B, so far, no effective vaccine has been found for hepatitis C virus. The fundamental precautions against both types of viral hepatis consist in non-specific prevention related to the means of transmission of infection, namely avoiding contact with blood and other body fluids of any infected person. Both hepatitis B and C are most frequently trasmitted parenterally, by means of sexual intercourse, vertical transmission is less common. Before the introduction of screening tests for blood donors, viral hepatitides B and C were most frequently transferred via blood transfusion. At present, intravenous administration of illicit drugs presents a major risk factor due to sharing needles, syringes and other instruments among users. The theoretical part of the thesis summarizes present day knowledge on viral hepatitides B and C. The practical part focuses on the incidence and means of transmission of viral hepatitis B and viral hepatitis C in the Central Bohemia Region within a 10-year period. I also aimed to examine viral hepatitides B and C transmission risks awareness, and safe-sex rules observation among a selected group of the Central Bohemia population.
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The role of educative nurse in the infectious diseases ward
PŘITASILOVÁ, Vladimíra
One of very important competences of nurses is educational activity. This research is focused on the educational activity pursued by nurses in isolation wards {--} how the nurses perform the educational activity, in what manners the activity is conducted and what problems inhibit nurses from performing the activity. It also examines clients{\crq} awareness and their opinions on the information provided by nurses. The objective of the thesis was to ascertain implementation of the educational process in isolation wards {--} to ascertain clients{\crq} awareness of the care of their health in isolation wards and to ascertain preparedness of nurses to perform the educational activity. In order to fulfill this objective and to confirm hypotheses, a quantitative research using the method of examination through questionnaires was applied. Two questionnaires were drawn up: one for the recipients of the educational activity {--} patients/clients and the other one for the providers of the educational activity {--} nurses. The examination through questionnaires was undertaken by 177 informants of which 96 were patients/clients and 81 nurses. The data were processed by way of the descriptive statistics using diagrams. The research was conducted in five hospitals. Three hypotheses were raised. Nurses working in isolation wards perform the educational activity. Clients of isolation wards are informed about the care for their health. A general nurse of an isolation ward possesses skills to perform the educational role. All the three hypotheses have been confirmed on the basis of the implementation and the analysis of the research. It follows from the data analysis that the educational activity pursued by nurses is important. A positive finding is that the nurses working in isolation wards implement the educational process, feel the need of further training in the area of education and communication, and are interested in application of their competences also in particular areas of the work with HIV-positive clients and with the clients suffering from chronic infectious hepatitis. It is obvious from the research that the objectives that had been set have been attained. It is necessary to address the topic henceforth since some problems have appeared in the educational process, hindering nurses from performing the educational activity. These are insufficient spatial, time and material conditions that can be solved through the proposed organizational and personnel measures.
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Health hazards perception of intravenous application of psychoactive drugs in addicted group
PROKŠOVÁ, Michaela
The addiction psychoactive substances currently represents a major problem. The number of users of such substances has been increasing. The intravenous application of psychoactive substances is associated with many health risks. Transmission and spreading of infection is associated mainly with frequent sharing and use of needles, syringes and other instruments among the users. In recent years the spreading of hepatitides (particularly VHC) has been reported as one of serious consequences of addiction to psychoactive substances, particularly in case of intravenous application. Protection against the spreading of diseases consist mainly in the prevention. The objective of the thesis is to verify whether the people addicted to psychoactive substances are aware of risks of transmission and spreading of infectious diseases (particularly VHC) as a result of intravenous application. The research was conducted on a group of drug addicts intercepted in the network of contact center and on a group of drug addicts in a therapeutic program of a psychiatric facility. I have used the method of inquiry in the form of questionnaires. In the thesis I set five hypotheses. The first, the third and the fifth hypotheses have been confirmed. The second and the fourth hypotheses have not been confirmed. The results of the research may be used by facilities providing low-threshold services as a part of secondary and tertiary prevention and harm reduction. It may also serve as source of information for workers dealing with anti-drug issues.
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