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Hypercoagulability and their occurrence in a population sample of young women
MARKOVÁ, Markéta
This work deals with hypercoagulable conditions, caused by shifting the natural balance towards the pro-coagulation processes which are associated with a heightened risk of venous thrombosis. The research part is divided into three parts. My laboratory work was conducted at the Department of Clinical Hematology at Czech Budejovice Hospital, where, in February I conducted hyper-coagulation tests. More specifically, factor VIII, lupus anticoagulant and the functional levels of protein C and protein S. Other reasearch activities included the evaluation of patients who had been examined over a period of one year and the frequency of occurrence among different age and gender groups. The highest occurrence was observed, as expected, with women aged 18-39 and elderly men. The last part of the paper is a questionnaire on how women are informed about the risk factors of thrombosis, family history and risks for individual respondents. We managed to isolate 7 potentially vulnerable women whose families (more precisely their parents) have a history of thrombosis, and who take hormonal contraceptives.
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Thrombophile gene mutations and their health social complications
ŠTORKOVÁ, Marie
The objective of this thesis was to describe trombophilic gene mutations from the health and social viewpoint and to find out if these innate trombophilias may also cause psychosocial complications. The thesis consists of two sections: The theoretical section deals with the genetic nature of trombophilic gene mutations, their health and social complications. Practical information for life with trombophilias is also given. The practical section of the thesis was carried out by means of quantitative research, using the technique of anonymous questionnaires. The questionnaire consisted of 24 questions. 3 questions were stratificational. 21 questions were related to the issue concerned {--} trombophilic gene mutation complications, 7 questions of which were focused on health complications, 6 on psychosocial complications and 8 questions were aimed at finding the respondents´ awareness on their diagnosis and sources of information. The questions number 8 {--} 15 were addressed only to women. The chosen set of respondents were persons addressed through web servers Baby-café.cz and Doktorka.cz (97%) and clients of the Association of Samaritans of the Czech Republic Rescue Service Prague {--} west (3%). The total number of respondents was 86 (100%), 77 of whom were women (90%) and 9 (10%) men. The questionnaires were evaluated and the data were turned into graphs. The hypothesis saying: ``Trombophilic gene mutation complications are not only connected with physical health, but they are also psychosocial{\crqq} was confirmed according to the research results. The results show the need of better awareness and point out to the importance of possible complications prevention. The informative website made up on the basis of this research - http://www.trombofilie.estranky.cz/ - should contribute to better awareness and prevention of innate trombophilias complications.
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