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National Repository of Grey Literature 24 records found  beginprevious21 - 24  jump to record: Search took 0.01 seconds. 
Hodnocení postupů jednotlivých reaktivátorů AChE přes hematoencefalitickou bariéru
Žďárová, Jana ; Univerzita obrany.
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Úloha CNS v patofyziologii diabetu a inzulinové rezistence
Pelikánová, Terezie ; Kazdová, Ludmila ; Institut klinické a experimentální medicíny
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Změny neurohistologického obrazu edému mozku po intrakarotické aplikaci neuroprotektivních látek otevřenou hematoencefalickou bariérou v experimentálním modelu in vivo a perspektiva neuroprotekce v neurochirurgii
Kozler, Petr ; Pokorný, Jaroslav ; Ústřední vojenská nemocnice (Praha, Česko)
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HPLC determination of oximes in biological samples
 PROCHÁZKA, Petr
Reactivators of acetylcholinesterase inhibited by organophosphate inhibitors play an important role in organophosphate poisoning therapy. There are a large number of reactivators being tested for their ability of penetration through blood-brain barrier (BBB) nowadays. The main aim of this thesis is to test this ability in four well know reactivators {--} HI-6, K-027, K-074 and TO-032. The 5% lethal dose (LD50) {--} therapeutic dose - of each reactivator was i.m. (intramuscularly) applied to experimental animals (Wistar rats) into right posterior thighs. Then the animals were sacrificed and the blood (plasma) and brain were collected for HPLC analysis. Subsequently, brain and plasma were frozen at -80 °C and stored until the assay. The reactivator concentrations were measured in plasma and four parts of the brain {--} frontal cortex (FC), basal ganglia (BG), ponto-medullar part (PM) and cerebellum (Ce). There were five animals for each group used for the purpose of the experiment. The concentrations of reactivators in plasma and blood samples were measured using HPLC-UV/VIS methodology. HI-6 concentrations CFC were on the average 4.29% of Caverage in plasma, CBG were on the average 1.9% of Caverage in plasma, CPM were on the average 2.3% of Caverage in plasma, and CCe were on the average 1.85% of Caverage in plasma. These rates were counted from all concentrations within the scope of particular observed parts of the brain. All the other tested reactivators were not quantified in brain at all.
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National Repository of Grey Literature : 24 records found   beginprevious21 - 24  jump to record:
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