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Cell therapy in animal models - preclinical studies
Juhásová, Jana ; Motlík, Jan (advisor) ; Grim, Miloš (referee) ; Jendelová, Pavla (referee)
The progress of cell therapy can be greatly facilitated by using suitable experimental models. It is essential to verify the clinical usefulness of new healing procedures obtained in studies on laboratory animals by using a large animal model. One of suitable models well acceptable in medical community is undoubtedly the miniature pig, which resembles humans in terms of physiology and body proportions. This PhD thesis presents the summary of our experimental studies relating to possible exploitation of mesenchymal and neural stem cells in the healing of locomotive apparatus and neural tissue disorders in humans or animals. The first part of the thesis briefly describes the current issue of cell therapy and animal models, mesenchymal cells and/or their combination with new types of scaffolds, neurogenesis, neural stem cells and their potential application in therapy of spinal cord injury. The second part is focused on the goals and methodology, the individual publications being listed in the third part. Our experiments with iatrogenic physeal defect in rabbits, which served as a model of the occurrence of valgous deformation in the clinical practice, showed the positive preventive and therapeutical effects of a new type of scaffolds seeded with allogeneic mesenchymal stem cells in animals without...
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Rendering Planetary Atmospheres in Real-Time
Elek, Oskár ; Maršálek, Lukáš (referee) ; Kmoch, Petr (advisor)
In the field of photorealistic rendering of physical phenomena, the rendering of atmospheric light scattering takes a very important place. Realtime rendering of sky and atmosphere in general is essential for all outdoor computer games, various simulators, virtual worlds or even for animated movies. It is a very difficult task, but thanks to the advancement of dedicated graphics hardware we can reach it today. In my thesis I present an accurate and fast method for real-time rendering of planetary atmospheres. This is achieved by precomputing complex single-scattering equations into a set of lookup tables. The correct atmospheric colour values are then fetched from these in the fragment shader. The presented method is then implemented in a program that is capable of rendering realistic atmosphere in hundreds of FPS.
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Study of pheonotype of the H9c2 cells derived from rat cardiac myoblasts
Kutichová, Martina ; Šimůnek, Tomáš (advisor) ; Vostatková, Lucie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Martina Kutichová Supervisor: Doc. PharmDr. Tomáš Šimůnek, Ph.D. Supervisor - specialist: Doc. MUDr. Michaela Adamcová, Ph.D. Title of diploma thesis: Study of phenotype H9c2 cells derived from rat cardiac myoblasts The cell-based in vitro investigation represents an important and frequently employed platform in current biomedical research. In experimental cardiovascular research, enzymatically dispersed neonatal or adult cardiomyocytes from various animal species are considered as a "gold standard" for such experiments. However, besides isolated primary cultures, permanent cell lines are becoming extremely popular among cardiovascular scientists. H9c2(2-1) is the first permanent cardiomyocyte-derived cell line. Although these cells are known since the mid-seventies, there is not much information about their phenotype. This study followed the results of the shotgun proteomic analysis, which identified about 1500 proteins. The aim of this thesis was to continue with obtained proteomic results with focus on detection of specific proteins by Western blot method. H9c2 cell were studied for the presence of several muscle and/or cardiac specific proteins in both non-proliferating H9c2...
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Animated feature-length movies and their position in Czech cinemas
Králová, Pavla ; Hanzlík, Jan (advisor) ; Blažková, Eva (referee)
This thesis discusses the animated movies, which are distributed to cinemas, and Czech moviegoers. It presents the historical progress in feature-length animated movies followed by their distribution to Czech cinemas. It focuses on film marketing and then characterizes Czech moviegoer. The practical part of thesis analyses the change of the position of feature-length animated movies in Czech cinemas during certain period of time. The analysis is followed by questionnaire aiming to discover why people go to the cinemas to watch animated movies. The conclusion contains the comparison of the results of questionnaire with the hypothesis and the position of feature-length animated movies in Czech cinemas.
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Conditions for Emergence of Art and Originality in an Animated Film
Vizár, Matúš ; KUBÍČEK, Jiří (advisor) ; DUTKA, Edgar (referee)
This bachelor thesis is an analysis of satirical processing of religious themes in the TV show South Park. It deals with the origin of satire, its power and the critical exploitation. Text is divided into the chapters according to the religions more described in the show (except islam). The thesis focuses how the authors work with the humor, what the message of the each part of the show is and why this show or satire is important for our society.
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Human and animal ear, comparative anatomy and physiology
Šlehobr, Ondřej ; Zahradil, Jaromír (advisor)
The topic of her thesis, which deals with the comparative anatomy and physiology of the human and animal ears, I decided for several reasons. Above all, it is my long-standing interest a morphological study, and no less importantly, io nature as a whole. In the following chapters using literature trying to outline the structure and function of static and sound system for each class of vertebrates. Due to the phylogenetic background, the first two chapters dealing with invertebrates, which have long before the development of their own labyrinth system created to allow authorities orientation in space, and can later feel the vibrations caused by sound. In subsequent chapters describes the anatomy and physiology of the ear fish, amphibians, reptiles, birds and mammals, with regard to the development of the sound system, since static apparatus from the class of fish found in virtually the same state in development line up to person. The chapters on fish and amphibians are also described specific mechanoreceptors, forming lateral sensory line. This represented primarily by water Vertebrate hearing and allow to perceive sound vibrations fluid in animals yet are not of special organs of hearing. Due to the same embryonic origin and innervation can be very sensual side line as the predecessor labyrinth authority....
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Parazitostatus of red deer population in farm and results of its control
Myšíková, Markéta ; Lamka, Jiří (advisor) ; Ducháček, Lubomír (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Markéta Myšíková Supervisor: Prof. RNDr. Jiří Lamka, CSc. Title of diploma thesis: Parasitostatus of red deer population in farm and results of its control This thesis deals with the evaluation of internal parasites in imported red deer population (New Zealand, Hungary). In the period beginning with the first health examination in 2007 through 2010 were collected faecal samples from animals and subjected them by parasitologic testing for infectious stages of gastrointestinal tract round worms, flukes, and tapeworms. We used qualitative ovoscopic examination and quantitative methods of larvoscopic examination. We found that regular treatments with marocyclic lactone based on ivermectin ensured sufficient efficacy against all types of parasites that occurred in the tested population of red deer (Fajdal, Slovakia). Keywords: red deer, parasites, farm, ivermectin
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Painterly animation synthesis
Psotka, František ; Maršálek, Lukáš (referee) ; Pelikán, Josef (advisor)
In this work I study painterly animation synthesis using simulated brush strokes. Painterly animation, as a new artistic form, gives the animator new space and freedom. The aim of the project is to design a framework which could solve this complex task - to put together both the exibility and simplicity with user comfort. This framework should be helpful in further research of artistic and technical potential of painterly animation. Implementation the method of Barbara Meier [4] within this framework results in the application which provides a possibility of creating attractive pieces in brushwork even for less experienced animators.
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Pojištění průmyslových rizik
Polesný, Michal ; Dohnal, Radim (advisor)
Práce se zabývá zmapováním nabídky produktů pojišťoven v oblasti pojištění podniků o majetkové základně s pojistnou hodnotou vyšší než 50 milionů korun. Cílem její první části je analyzovat rizika, která jsou pojistitelná, a najít k nim odpovídající pojistné produkty. Druhá část práce se věnuje jednotlivým parametrům pojistných smluv a srovnání produktové nabídky předních českých pojišťoven na základě konkrétních dat dodaných přímo samotnými pojišťovnami. Závěrečná část práce má pak odpovědět na otázku, jak finančně náročné pojištění průmyslových rizik je a nakolik může podnik tuto finanční náročnost ovlivnit výběrěm jednotlivých pojistných produktů či jejich kombinací.
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Overcoats
Trnka, Matyáš ; KUBÍČEK, Jiří (advisor) ; Mertová, Michaela (referee)
Bachelor thesis Overcoats presents unrealized projects (mostly films) of seven czech major directors of animated films. Text contains samples from specific projects, accompanying text of author of the thesis, which puts works into larger context and interviews which was made directly with authors of projects or the individuals most connected. Interviews were taken, rewritten and modified in July and August 2016.
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