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HPLC Determination of Lutein, Zeaxanthine and Betacarotene in Dietary Products
Dvořáková, Petra ; Šatínský, Dalibor (advisor) ; Chocholoušová Havlíková, Lucie (referee)
This rigorous thesis deals with modification of method for separation carotenoids lutein, betacarotene and zeaxanthin borrowed from diploma thesis (Optimization of chromatographic conditions for HPLC determination of chosen carotenoids, Petra Dvořáková, 2009). HPLC with VIS detection is the basic method. This method was modified by gradient elution for compressed time of analysis. Four ways of gradient elution were tested during optimization of new procedure. The second aim of this rigorous thesis is summary of extraction ways for carotenoids published in special literature and proposition of extraction procedures for carotenoids from dietary products. Extraction with organic solvents was used during searching for optimal way for extraction. Simple extraction with organic solvent was tested as basic method, but extraction with previous modification of sample (saponification or acidification of extraction medium) was tested too. In spite of testing of many various ways for extraction and many various organic solvents, there wasn't find optimal and universal extraction way.
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Inventory models - shortcomings, the necessary adjustments and improvements for real use of models in companies and supply chains
Červenka, Daniel ; Kuncová, Martina (advisor) ; Kořenář, Václav (referee)
The aim of this thesis is to find the appropriate manner for inventory control of a small e-shop. The greatest emphasis is placed on the nonseasonal goods. Any model which respect all needs of the shop was not found. From a series of models the stochastic model with continuous demand was chosen as the most applicable. Adjustment of the cost function, change the delivery time from constant to fluid, determination of optimal inventory level and other modifications brought the model more in reality. This allows to find the optimal model solution for each stock item which can be reasonably well met. Simultaneously the foundation were laid for post-optimization analysis, by which all the process of inventory control can be streamlined.
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Optimization of chromatographic separation for the determination of 4-aminophenol and active substances in Valetol
Daňková, Jana ; Šatínský, Dalibor (advisor) ; Sklenářová, Hana (referee)
This thesis deals with the optimization of separation conditions determine paracetamol, caffeine, propifenazone and 4-aminophenol in Proprietary Medicinal Products Valetol. As an analytical method was chosen HPLC with UV detection mainly for the following reasons: many other tablets contain excipients which are from the sample during analysis impossible, and separated themselves determination of active substances to monitor the stability of active substances The work was conceived as original, and the emphasis is on the greatest possible simplicity and less time consuming and optimized separation while maintaining high accuracy and reliability of the method. Optimal conditions suitable for the final validation of the separation were found on a column of C-18 RP-amide. Total analysis time does not exceed 13 minutes with equilibration after gradient elution of the column to its original condition. All substances are separated with a resolution greater than 1.5. The peaks of substances are symmetric and do not show significant peak tailing besides AMF. The zero line is despite the gradient elution stable.
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Physiotherapy in patients after injuries of the spine and spinal cord
HAJNÁ, Petra
In connection with our lifestyle every year in our country but also abroad there is a growing number of people with spinal cord injuries. The spinal cord injury usually occurs while a spinal injury, where the spinal canal is compressed by luxated vertebra or bone fragments. Affected are more often young people, especially men. The most common causes are falls from height, accidents and sports injuries. A person with this condition not only has limitations in terms of loss of movement or sensitivity but is often threatened by various health complications. Therefore a complex care and intensive rehabilitation is very important, which is in the Czech Republic secured by the spinal program lasting 6-9 months. Rehabilitation is needed not only in the acute period after injury, but has a unique place in the chronic stage of spinal cord injury as well. The aim of this thesis was to explore issues of trauma and spinal cord injury from the perspective of physiotherapy. Based on the defined targets following research questions have been determined. What kinds of physiotherapy procedures may be used onpatients in the subacute stage and what procedures in the chronic stage of spinal cord lesion. A qualitative research in the form of case reports has been executed. Data was obtained from interviews, observation, document analysis and kinesiological analysis. Standard tests related to the spinal lesion were performed, only the most relevant tests and the results that were found during therapy in case reports were entered. The sample included four patients. Two patients in the subacute and two patients in the chronic stage of spinal cord injury lesion etiology. The research was conducted at the Spinal Unit Department of Traumatic Surgery, University Hospital Brno and at the Rehabilitation and restoration center Borovany. Physiotherapy in subacute phase of spinal cord injury is directed at the prevention of pressure sores, contractures, pain, maintaining optimal mobility of joints, focusing on respiratory rehabilitation, maintenance and strengthening of preserved motor potential, activation of the motor transient spinal cord lesion with efforts to activate the motor skills in the most distally way, improving the overall physical condition. The aim is to use and support functional ability of the patient to the fullest extent and quality with the subsequent effort to develop alternative mechanisms.Of the special methods the ones on the neurophysiological basis are the most commonly used treatment methods. An important part is the gradual verticalization of the patient, training equilibrium reactions such as training seat, support for upper limb, keeping in certain positions and functional training, thus the mobility on the bed, self-care, transfers, training wheel chair control, practicing functional replacement grip. Patients return to life with a big handicap, are often dependent on the assistance of others, learn to use a wheelchair and other aids. They have years of life ahead in which they have to cope with the conditions subsequent their injury. In the chronic period, it is important to maintain physical fitness, preventpossible complications, especially pressure sores and joint contractures. Physiotherapist addresses the consequences of overloading the exposed muscles, monitors the vertebral problems, joint pain or muscle imbalance. During this period, patients can attend ambulant physiotherapy or use maintenance stays in rehabilitation centers. The purpose of the study was to mention the basic and the most important areas in the care of spinal patients and to highlight the importance of physiotherapy comprehensive care not only within the spinal program, but also from the perspective of the long-term care of these patients as the rehabilitation should accompany the patient's whole life.
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Managament of changes in IBEROFON CZ, a.s.
Skrášková, Monika ; Svobodová, Hana (advisor) ; Lorenc, Miroslav (referee)
This writing describes operation management and management of changes in IBEROFON CZ company and it is focused on management of changes analysis in 2005 -- 2008 period. Operation management represents processes, which goal is optimal workfllow with efficient input usage. Management of changes is characterized as group of processes which relates to additional product technological or construction documentation.
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Comparing of the Police ČR and Metropolitan police competences, objectives and education system with the view to more intensive cooperation between the both institutions.
ŠKOLKOVÁ, Věra
This thesis deals with the tasks, activities, competences and education system of police and city police in order to comparing and proposing of the methodological tools for effective and efficient cooperation between the two components. Although each component has a very different structure and organization and substantive and territorial jurisdiction, activities of city police in some areas closely linked with the activities of police (supervision of public order in the city) or it is linked to the activities of police (reporting of crimes the police). Currently, there is necessary that the both components cooperated with one another, have functional channels and are constantly informed about important matters that take place within the activity of the components (police inform about search persons, about robberies, burglaries). Similarly, the education system and its form in the police and local police is very different simply because the police as a component of the state is organized from the central level, while the individual city police is controlled from the local level. Therefore depends on the decision of who controls the local city police, what kind of above standard training would provide police officers and what funds can allocate to this training. Currently, many city police have more available funds for equipment, instrumentation or training than the police, but on the other side missing some permissions that would help them operate more efficiently. The minor modification of an existing legislative authority of the municipal police would often resolve cases without the same time necessary police assistance The aim of this thesis is to outline how the city police could cooperate with the police more intensively and effectively in cities, provided that they solved some minor problems, and also propose optimal level of police officeres training in cities.
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The history of the European monetary unions
Přílepková, Hana ; Půlpán, Karel (advisor) ; Pazderník, Roman (referee)
This thesis depicts monetary integration of the European states from the second half of the nineteenth century to the period after the First World War, which was taking place against the background of the then metallic monetary systems. The aim is to provide a comprehensive view of the historical developement of integrating tendencies and to reveal the reasons of its successes and failures. The first part provides a brief theoretical introduction, the stress is putted especially on the theory of optimal currency areas. The remaining parts deal with monetary unions of the surveyed period. Firstly we look at the ways in which national and multinational monetary unions of the nineteenth century were realized. The spontaneous adoption of the gold standard by the majority of countries in the 1870s created world monetary union based on a system of fixed exchange rates. Finally we focuse on the Austro-Hungarian monetary union. Powered by TCPDF (www.tcpdf.org)
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Development of the selected city using methods of strategic management
GRUZOVSKÁ, Sandra
The principal aim of the thesis is to evaluate the current situation of selected city by the methods of strategic management and design of optimal strategy for its further development.Fractional objectives were to determine the internal state of the city, through a summary of strengths and weaknesses, and to determine the external condition by transcrabing options, as well as threats that the city can expect. Another objective was to detect groups or organizations that affect the city or the city has a contrary effect upon them. Also, the aim was to determine the point of view of city management at their strategic management of the city and to determine the point of view of residents of the city at its course and services.
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Optimal digital terrain model for erosion analysis
Středová, Kamila ; Brychta, Jiří (advisor) ; Rejha, Vít (referee)
The thesis deals with the question of using available sources of elevation data for the evaluation of topographic factor in estimating the amount of water erosion in the area. Work compares the results with consideration to the origin of the data, the accuracy and resolution of the digital terrain model, which is interpolated from the source data. The calculation of topographic factor in ArcGIS will be confronted with the results of the Universal Soil Loss Equation (USLE). The frequency of compliance will tell us which data source and digital terrain model resolution is the most suitable for determining the topographic factor.
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Decision making in the initial phase of the architectonic project
Moučka, Jan ; Starý, Oldřich (advisor) ; Štursa, Jiří (referee) ; Zich, Otakar (advisor)
Předmětem aspirantské práce byla racionalizace rozhodování v počáteční fázi projektování budov a úprav prostředí, tj. od většinou vágního zadání až po návrh disposice budov. Jako metodu racionálního rozhodování problémů zvolil aspirant formální logiku, teorii grafů, využití počítačů. Obsahem disertace jsou i obecně srozumitelné pasáže, s ohledem na obsah vysokoškolské výuky architektů. Hlavními výsledky aspirantury je pojmové zpřesnění, model a metoda řešení problémů slučitelnosti činností ve společném prostředí (místnostech), uspořádání a propojení místností v jednopodlažních budovách (disposiční řešení). Aspirantura probíhala při zaměstnání ve výzkumu výstavby, její výsledky byly podkladem pro úkoly, které aplikovanému výzkumu byly zadávány. Přílohou je grafický výstup výpočtu optimální rozsáhlé disposice z r. 1967, pomocí programu "Rovinný rozvrh", jehož autorem byl Jan Moučka za spolupráce matematiků- programátorů. Školícím místem bylo ČVUT, Fakulta architektury. Školiteli byli prof.ing.arch. Oldřich Starý a univ.prof. Otakar Zich DrSc, vedoucí katedry logiky University Karlovy. Oponentem byl prof.Jiří Štursa.
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