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IL-25: Novel target to treat allergic diseases
Lišková, Kateřina ; Hrdý, Jiří (advisor) ; Boháčová, Pavla (referee)
Interleukin (IL) 25 is a proinflammatory cytokine that promotes a Th2-type cell response. Its alternate name is IL-17E, and along with 5 other members, IL-25 belongs to to the family of cytokine IL-17. The family is based on the similarity of their amino acid sequences. The source and target cells of IL-25 include many different cell types. IL-25 is not only produced by many types of immune cells, but epithelial and Paneth cells are involved in its production as well. Its receptors form heterodimers composed of 2 subunits - IL-17RA and IL-17RB. Both receptor proteins are required for IL-25 mediated activities and occur in other IL-17 family members. IL-25 also plays an important role in allergies - one of the most common diseases in developed countries. Cytokine IL-25 has been studied primarily in asthma. However, other very common types of allergies, such as food allergies, atopic dermatitis and allergic rhinitis, can not be overlooked. Even in these cases, the role of IL-25 is not negligible and is studied. Based on the knowledge of IL-25 biology and its role in allergies, this cytokine may be an important therapeutic target in the treatment of allergic diseases. One possibility is, for example, the use of neutralizing antibody and subsequent blocking of IL-25 activity. Key words: interleukin-25,...
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Sport activities with asthma bronchiale diagnosis
Klinerová, Hana ; Hronzová, Marie (advisor) ; Hájková, Jana (referee)
This work examines the influence of asthma on children's sports activity. Tested were nine children with asthma bronchiale, athletes and non-sportspeople, using a test battery UNIFITTEST (6-60). The work compares the results of the children tested with results that indicate standardized tables for children of the same age. It explores whether the results will vary greatly and will be the same. The information obtained was processed into tables. Keywords: Asthma bronchiale, sport activities
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Asthma In Children's Population and the Enviromental Factors In Selected Towns of the Czech Republic
Fiala, Josef ; Kazmarová, Helena (referee) ; Dzúrová, Dagmar (advisor)
The aim of this thesis is to give information about asthmatic disease, to evaluate the situation in Czech children's population and to analyze the impacts of selected environmental factors on the occurrence of the bronchial asthma in selected age group. In the first part of this thesis are the information about bronchial asthma. In the second part of this thesis are description of the data of selected children group and characteristics of the environment (the source of data was from Czech National Health Institute). There are verifications of the null hypotheses about the risk effect of the environmental factors on the occurrence of the bronchial asthma among 5-years-old children in selected towns of the Czech Republic. The selected towns are České Budějovice, Hodonín, Hradec Králové, Jablonec nad Nisou, Jihlava, Karviná, Kladno, Mělník, Most, Olomouc, Sokolov, Ústí nad Labem, Ústí nad Orlicí and Žďár nad Sázavou.
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Art therapy when working with children with asthmatic disease
BROUMOVÁ, Zulika
Art therapy when working with children with asthmatic disease. This thesis deals with the effect of art therapy techniques for children and youth suffering from asthma. The theoretical part deals with the diagnosis of asthma, history, present, psychosomatic. It characterizes children with the diagnosis of asthma, further describes the possibilities of psychotherapy, forms and methods of art therapy. The practical part includes characteristics of research sample and the enviroment, art activities. It describes and evaluates the options and the use of art therapy for primary school children.
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Creation and testing of educational program: Health education and prevention of non-infectious disorders (asthma, chronic obstructive pulmonary disease)
CHUDÁRKOVÁ, Kateřina
The bachelor thesis deals with the design and applicability of an educational program intended for students of the master course Education with a focus on health education. The educational program is aimed at health education and the prevention of non-infectious diseases asthma and chronic obstructive pulmonary disease. In the introductory theoretical section I analyse concepts like health, prevention, lifestyle and disease. The central theme focuses on the chronic obstructive pulmonary disease, asthma and smoking, which has a decisive role in the development of both diseases. In the practical section I verify the applicability of the educational program by comparing the input and output tests, which give evidence about the level of knowledge on the topic in question of randomly chosen students of the course Education with a focus on health education. The results of the practical investigation confirm the feasibility of the program in practical use and its considerable impact on deepening students' knowledge in the studied topic.
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The development of musicality in children at a pre-school age with a focus on correct breathing while playing the flute.
KOLÁŘOVÁ, Lucie
The aim of this bachelor thesis was to introduce the musicalness of the pre-school-aged children and its development. Topics connected with fipple flute - its history, application during teaching of the pre-school-aged children and mainly chapters focusing on the correct breathing while playing the instrument, can also be found in the work. The thesis mentions a distinguished Czech teacher of the fipple flute Vaclav Zilka and his cooperator docent Vit Petrů. Professor Zilka has continued his project called "The Wooden Flute" with another project - "Healing Flute" and significantly contributed to the recovering process of the children afflicted with asthma and other breathing difficulties. He has also created a well-organized and a simple-to-use course book fot small flute players, which involves basis of playing the musical instrument as well as several practical breathing exercises.
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