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Optimalization of HPLC Separations of Basic Molecules of Betablockers - application of New Types of Sationary Phases
Svoboda, Antonín ; Nováková, Lucie (advisor) ; Šatínský, Dalibor (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department: Department of Analytical Chemistry Candidate: Mgr. Antonín Svoboda Consultant: PharmDr. Lucie Nováková, Ph.D. Title of thesis: Optimalization of HPLC separations of basic molecules of betablockers - application of new types of sationary phases Beta blockers are pharmaceutically active substances, which affect on betaadrenergic system of human bodies. These drugs are used for various indications, particularly for the management of hypertension and cardiac arrythmias. The substances are chemically mostly basic non-polar compounds. In this thesis HPLC separation of seven betablockers on different stationary phases was tested. The optimal conditions for separation were found by changing composition, pH and elution mode of mobile phases. In some cases temperature was also optimized as a variable. The different conditions were compared in terms of retention, resolution and symmetry of peaks. The stationary phases were compared by System suitability test under the optimal found conditions. The results were acceptable on the Extra Densely Bonded and Double Endcapped C18 stationary phase Zorbax Eclipse-XDB. Zorbax Extend C18 column incorporating a patented bidentate silane with double- endcapping protection enabled measurements...
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Maltese Temples. Architecture and evolution
Pšurný, Jiří ; Stančo, Ladislav (referee) ; Musil, Jiří (advisor)
This thesis discuss the chalcolithic temple structures in Malta. It focuses on their structure, architecture, disposition and materials which were used to build them. It is interested in the first settlements in Malta. It considers decoration of the temples - reliefs, paintings and statues. It discuss rituals, which were performed here and connection between the orientation of the temples and motion of the space bodies. There is catalog of the main temples in Malta and there is catalog of the hypogeums as well.
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Property of the Moon – Provision of International Public Law vs. Private Initiatives
Lupač, Petr ; Trávníčková, Zuzana (advisor) ; Kochan, Jan (referee)
The goal of this thesis is to contribute to the understanding of the legal regulations of Outer Space and the Moon and to answer the question of whether the sale of land on the Moon is in accordance with international law. At first, the author will define the term of international space. Secondly, Outer Space which is predominantly exulted by the fundamental instrument of space law - the Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, including the Moon and Other Celestial Bodies - will be characterised. This legal regulation is further expanded on by the Agreement Governing the Activities of States on the Moon and Other Celestial Bodies. Attention will also be given to private initiatives relating to purported claims to proprietary rights to plots of land on the Moon. The thesis will evaluate the arguments arising from international law as well as the arguments from the sphere of private initiatives. The last chapter will include an analysis of the legal regulation of mining of the Moon's natural resources and the proprietary claims thereto.
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N-Body Simulation Program
Kollárová, Martina ; Martinek, David (referee) ; Peringer, Petr (advisor)
The n -body problem simulator predicts the motion of celestial bodies by numerically integrating the laws of motion. Gravitational interactions are computed directly between the bodies using Newton's classical mechanics and the bodies are modelled as point masses. The application animates the problem and will be available under the GPL licence. It can be used while teaching continuous simulation to show accuracy differences between numerical integrators with various time steps. It can also serve as an experimentation tool for physics students. Some basic examples are included in the project, like the Solar System and the three body problem with the Earth, Moon and Sun.
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Current problems of the use of outer space and celestial bodies
Krejčí, Jan ; Kochan, Jan (advisor) ; Trávníčková, Zuzana (referee)
This thesis focuses on problems of the use of outer space and celestial bodies, namely on problems of space debris, use of space resources and further development of the space law. The objective of the thesis is to identify possible solutions to these problems. Analyzing the problems of space debris, we came to the conclusion that it is necessary to continue in implementing directives and international treaties about mitigation of space debris as well as in development of technologies for active removal of space debris. The problems of the use of space resources were addressed using the present space law and failed attempts to appropriate parts of the outer space and celestial bodies. By means of legal documents of UN, international treaties and directives, we revealed the trend in the international space law which lies in more and more voluntariness of legal instruments. The result is finding out that cosmic cooperation takes place more on the level of cosmic agencies and less on the level of states. Contribution of this thesis consists in the presentation of current trends in the cosmis law and in the use of outer space and celestial bodies.
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