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Granulometry of nanoparticles from aliphatic acids copolymers.
Šrejma, Robert ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
The diploma thesis is focused on the study of influence on the composition of the system to the size of the nanoparticles from aliphatic polyesters with linear and branched molecules constitution. The emulsion method for distributing of solvent was chosen for preparation of nanoparticles. The theoretical part describes the nanoparticles, its origin and application. The following part is applying to biodegradable polymers, especially PLGA. There is also a mention of antifungal agent terbinafine. The nanoparticles are prepared of this substance. The process is described in the experimental part of thesis. The experimental part is testing different composition of samples. A main emphasis is on the choice of polymer solvent and emulsifier. There are also applied mixtures of solvents and emulsifiers. The important aspect is the evaluation of incorporated terbinafine, which has been the model drug. Prepared dispersions were exposed to stress conditions in the form of several days-storage and centrifugation.
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Machinable bioceramic foams prepared by gelcasting method
Šťastný, Přemysl ; Částková, Klára (referee) ; Trunec, Martin (advisor)
Diploma thesis is focused on development of method for preparation individualized bioscaffolds prepared by milling of HA foam prepared by gel casting method and consolidated via epoxy curing reaction. Diploma thesis continues in bachelor thesis Modern processing methods of porous bioceramics. Literature search is filled in the newest knowledge from the field of bioactivity enhancement of scaffolds. Experimental part of diploma thesis described development of system for individualized scaffold manufacturing from HA suspension preparation, preparation of ceramic blocks used as material for machining to final blocks machining. Pressure strength of foam were evaluated, too. Chosen samples were coated with calcium polyphosphate coating for biological response enhancement. Coated samples were given for in-vivo test to partner university in Beijing under the terms of project FP7-NMP-2013-EU-China: "Bioscaffolds"
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Thermal spraying of suspensions and solutions
Mušálek, Radek
Recently beginning to be selected for some applications of thermal spraying interesting administration of nanometric or micrometric powders in suspension, or preparation of particles from a solution directly over zinc deposition. This paper provides basic information about this new route of administration and its benefits for technical practice.
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