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Influence of solvent on the size of polyester nanoparticles
Königová, Eliška ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Univerzita Karlova v Praze Farmaceutická fakulta v Hradci Králové Katedra farmaceutické technologie Studentka: Eliška Königová Vedoucí diplomové práce: Doc. RNDr. Milan Dittrich CSc. Název práce: Influence of solvent on the size of polyester nanoparticles In the theoretical part of this thesis the methods of fabrication of nanoparticles and their evaluation are described. It further explores the biodegradable polymer of glycolic acid and lactic acid and in particular the nanoparticles prepared from this polymer. The main objective were the results of an experiment which explored some of the technological parameters of formulation of biodegradable particles made from terpolymer of DL-lactic acid, glycolic acid and tripentaerythritole by o/w emulsion method. The aim was to create the smallest possible nanoparticles using the standard procedure. The study sought the optimal concentration of emulsifier cetrimide. It evaluated the influence of the concentration of emulsion and the concentration of the polyester carrier and terbinafine as a model drug for the assessment of granulometric parameters of prepared particles. For an intended use of the method the storage of samples at low temperature after the addition of mannitol was granulometrically evaluated.
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Formulation of nanoparticles with terbinafine
Mrázková, Nikola ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Student: Nikola Mrázková Supervisor of Diploma thesis: Doc. RNDr. Milan Dittrich CSc. Title of Diploma thesis: Formulation of nanoparticles with terbinafine In the theoretical part of this diploma thesis is presented review concerning basic applications of nanotechnology in health service, characteristic of nanoparticles, their dividing and use in pharmacotherapy, especially in targeted drug transport. The focus of the thesis presented here is in experimental part. Particles of submicrom size were fabricated by the using of emusion solvent distribution method in the emulsion of o/w type. Star-like terpolymer of DL- lactic acid and glycolic acid branched on tripentaerytritole as core was used as potential drug carrier. The aim was to prepare the smallest particles as possible. The size and the size distribution were measured by the PCS method by the using of the device Zeta Sizer ZS. The impact of two from the chemical point of view different emulsifiers and two emulsion concentrations on the granulometric parameters of the prepared particles was evaluated. The stability of parameters during storage at lowered temperature and in the frozen state during the one day period after preparation was...
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Design of work station for pneumatic actuators assembly
Fuglíček, Ladislav ; Holub, Michal (referee) ; Tůma, Jiří (advisor)
Thesis deals with proposal lay – out assembly for pneumatic cylinder. Assembly is proposed into separate workplace. Single step are described in those work according to which workplace assembly are put together, division pneumatic cylinder to single constructional insider division and operation on single workplace and description these workplace. Analysis proposal is implementation in the end.
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The order processing by firm with usage of project management
Cagášek, Tomáš ; Chrobák, Petr (referee) ; Jurová, Marie (advisor)
GÁŠEK Tomáš: The order processing by firm with usage of project management The project laboured within the field of study with the name "Production tech-nology and industrial management" describes some versions of the potential job order's progress in the manufactory at the firm "Speciální strojírna, a.s.". A customer asks for the batch production of the casts, that he will be order step by step for working in regular intervals. The part of the customer's plan is the optimalization of the production and the press of the price, that should be lower after the finishing of the production technology. Along with the correction of the price, a customer expects cutting of the delivery time with the fully quali-ty of the working. In the first version, without a wide preparation, is all working realized on the general-purpose machines. The second version focuses on the production with use of drilling jigs, that is constructed and produced by the firm itself. The input costs of this preparation at the production will be compensated with the major production times, that will be destage from the expensive borer to the cheaper drilling-machine. The last third version supposes setting of the CNC machining centres and therethrough it will be reach to huge saving of the major and minor production times by the working.
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