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The effect of synovial fluid composition on friction of joint cartilage
Furmann, Denis ; Daniel, Matej (referee) ; Nečas, David (advisor)
This thesis deals with the study of the effect of the constituents of the model synovial fluid on the frictional properties of articular cartilage. The influence of constituents, concentration, speed and load is observed. Experiments were performed on a commercial tribometer at configuration pin-on-plate. Several types of lubricants containing synovial fluid constituents have been selected for the experiments. Lubricants were prepared at two concentrations, the concentration of healthy individuals and at a concentration typical of for osteoarthritic patients. Speeds 5 and 10 mm/s and 5 and 10 N loads were used for all experiments. It is shown that when using only lubricant containing proteins, no difference in the coefficient of friction is observed and the effect of concentration is also not observed. The addition of hyaluronic acid has a synergistic effect with -globulin, however in the case of lubricants containing albumin, the effect is opposite. After the addition of phospholipids, no significant effect on friction is observed in -globulin containing lubricants. No significant effect of the composition and concentration of the lubricants is observed with the load change.
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Dynamic vehicle-road interaction
Svršek, David ; Blaťák, Ondřej (referee) ; Fojtášek, Jan (advisor)
Bachelor’s thesis, Dynamic vehicle-road interaction, deals with a summary of basic knowledge about the acting force and factors that affect interaction of vehicle with surface. The work is divided into six parts, which deals with the definition of basic concepts and characteristics of dynamics, traction vehicle, braking, maneuverability, the chassis aspects influencing the traction and anti-skid road surface properties.
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Friction in forming proceses
Pažítková, Monika ; Dvořák, Milan (referee) ; Lidmila, Zdeněk (advisor)
This thesis deals with tests of forming operations, which are used to determine coefficient of friction. In the theoretical part of thesis, the individual tests are described in details, with the greatest emphasis on the upsetting test. In the experimental part of thesis was perform upsetting test on the cylindrical and ring samples. Coefficient of friction of the cylindrical samples was determined by a calculation method and ring samples were evaluated using diagram of calibration. The thesis includes comparison of the result received on lubricant and unlubricated samples and method for determined coefficient of friction. Graphite Delta 144 was used as a lubricant. This result show that the lubricant has a positive effect on forming process.
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Friction and lubrication of fascia
Chmelík, Jiří ; Daniel, Matej (referee) ; Vrbka, Martin (advisor)
The diploma thesis was part of the project "Regeneration and lubrication of fascia with hyaluronan" of the company Contipro a.s., whose main goal is the development of an injectable medicinal product. The number of patients suffering from so-called myofascial lower back pain is increasing. The cause of the pain is increased hyaluronic acid, which is produced between the layers of the fascia. If the viscosity is low, the fascia layers are not affected and the coefficient of friction is low. The purpose of the product is to improve the sliding movement of the fascia and relieve patients of pain. The main component of the medicine is hyaluronic acid. The project included rheological and tribological analysis of hyaluronic acid samples. A tribological model of fascia in a pin-on-plate configuration was created for the analysis of the coefficient of friction. Based on the fascia models used, the dependence between the coefficient of friction and viscosity of native hyaluronic acid solutions was found. For models and real fascias, the native solution (Bonharen) was found to have better friction properties than hyaluronic acid derivatives. These analyzes have contributed not only to the development of the drug, but also to the emergence of other studies that would like to address the biotribology of fascia.
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Analysis of contaminants in wheel and rail contact
Straka, Tomáš ; Galas, Radovan (referee) ; Kvarda, Daniel (advisor)
Wheel/rail contact is significantly influenced by so called third body – contaminants. Aim of this bachelor’s thesis is to analyse those contaminants in the contact and to create a brief overview. Short introduction into problem of wheel/rail contact is included, followed by description of main contaminants occurring in the contact. This thesis may be used as introduction into contamination of wheel/rail contact problem.
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Biotribology of artificial tears for the treatment of dry eye syndrome
Černohlávek, Mikuláš ; Daniel, Matej (referee) ; Vrbka, Martin (advisor)
This master thesis is a part of the project TAČR TREND, which aim is the development of new ingredient for treatment of dry eye syndrome. Developed ingredient is derivative of hyaluronic acid, which is in this thesis compared with native hyaluronic acids and commercial eye drops. Aim of this thesis is to describe rheological and tribological properties of measured samples in terms of viscosity, mucoadhesivity and coefficient of friction. Coefficient of friction was measured on created tribological model of the eye in pin-on-plate configuration which represents physiologically relevant sliding speeds of blinking. Comparison with native hyaluronic acids and commercial products of eye drops showed, that derivative reaches higher values of viscosity, has mucoahesive properties and has low values of coefficient of friction. Those key parameters show that modification of hyaluronic acid is promising way for drug development for dry eye disease.
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Software for Determination of Aerodynamic Losses
Ondrák, Adam ; Skála, Zdeněk (referee) ; Lisý, Martin (advisor)
This work deals with the creation of a program for calculating the tensile losses of an in-dustrial boiler. The work is divided into four parts. The first part of the thesis deals with a theoretical introduction to the issue of pressure losses. The second part deals with all equations and procedures by which the program was created, as well as the limitations and conditions of using a given type of equation. The third part consists of a sample calculation of pressure loss-es of a real boiler. Furthermore, in the third part, the correctness of the program function is checked, where the measured losses on the real device were compared with the losses calcu-lated by the program. The fourth part deals with the influence of the boiler's parameters on its pressure losses, where the individual losses were graphically represented and compared to determine the sensitivity analysis. The output of this work is a functional program that has been optimized for ease of use and requires almost no knowledge of the user.
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Influence of surface microstructure on implant lubrication processes in contact
Matovič, Martin ; Odehnal, Lukáš (referee) ; Ranuša, Matúš (advisor)
This bachelor thesis deals with the lubrication of microstructured prostheses of the first metatarsophalangeal joint. The aim of the research is the service life of joint replacements by creating a microstructure on the surface of the material. The work focuses on the influence of microstructures on lubrication processes in contact and coefficient of friction. Fluorescence microscopy in combination with a reciprocating tribometer with the possibility of recording frictional and loaded forces was used to observe the contact area. The number and average particle size of albumin, which plays an important role in contact lubrication, were then examined to record the camera. The testing was performed on two material combinations, namely CoCrMo - Glass B270 (hard pair) and CoCrMo - PMMA (soft pair), which were only four different microstructures. Elsewhere, the influence of microstructures on lubrication processes in contact for hard and soft pairs is indicated, which can be used to design further measurements.
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An experimental investigation of friction coefficient in hip joint replacements
Tkadlec, Tadeáš ; Urban, Filip (referee) ; Nečas, David (advisor)
This bachelor thesis deals with an experimental analysis of friction coefficient within hip joint replacements. The measurements were realized on Mini Traction Machine device in ball-on-disc configuration. The main goal was to determine the effect of implant material, kinematic conditions and model synovial fluid composition on the development of coefficient of friction as a function of time. For this purpose, three different materials (metal, ceramic, polymer), two mean speeds (5.7 mm/s; 22m/s), three different slide-to-roll ratios (SRR = 0 %, SRR = -150 %; SRR = 150 %) and six various model fluids containing albumin and -globulin in a various ratios and concentrations were employed. The results are evaluated in the form of graphs showing the dependence of friction coefficient on time and are confronted with previously published studies.
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