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National Repository of Grey Literature 12 records found  previous11 - 12  jump to record: Search took 0.01 seconds. 
Resistance to antimicrobial therapy of Helicobacter pylori strains
 Moravcová, Monika ; Keil, Radan (advisor) ; Nyč, Otakar (referee)
Helicobacter pylori (hereinafter referred to as H. pylori) is a gram-negative bacteria which colonises the human stomach mucosa. Its role in the aethiopathogenesis of chronic gastritis, ulcer disorders of the gastroduodenum and MALT-lymphoma has been clearly demonstrated, and in connection with the occurrence of stomach cancer it has been indicated by the World Health Organisation (WHO) as a class I carcinogen. H. pylori infection can be detected from samples of stomach mucosa taken in an endoscopic examination (rapid urease test, microscopic examination, culture), or the non-invasive method can be used (13 C-Urea Breath Test or H. Pylori stool antigen test - HpSA). Effective therapy of H. pylori infection resides in the administration of a combination of antibiotics and a proton pump inhibitor. In recent years the resistance of bacterial strains to used antibiotics has been increasing on a worldwide scale, and we can also observe this trend in the case of H. pylori. If the level of resistance exceeds 20 % for clarithromycin and 40 % for metronidazole, these antibiotics are not recommended for the treatment of an infection caused by this bacteria. In a group of 61 patients at the Department of Internal Medicine at the University Hospital Motol who had undergone an endoscopic examination of the...
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Voltammetric Determination of Metronidazol at a Polished Silver Solid Amalgam Composite Electrode
 Škvorová, Lucie ; Zima, Jiří (referee) ; Barek, Jiří (advisor)
The aim of this work was to find out the optimal conditions for voltammetric determination of metronidazole, which is used as an anti-tumor drug. The stability of stock solution of metronidazole in deionized water was monitored using UV-VIS absorption spectrophotometry. Optimum conditions for voltammetric determination of metronidazole at a polished silver solid amalgam composite electrode (p-AgSA-CE) have been investigated. The dependence of voltammetric behavior of metronidazole (1∙10-4 mol/L) on pH of analyzed solution has been investigated using DC voltammetry (DCV) and differential pulse voltammetry (DPV) in the pH range 2,1 - 12,1 in aqueous media of Britton- Robinson (BR) buffer. For electrochemically reducible nitro group of metronidazole, the mechanism of voltammetric reduction at p-AgSA-CE was proposed. The optimum medium of aqueous BR buffer pH 4.0 was chosen for measuring the concentration dependences for both voltammetric techniques. The concentration range 2∙10-6 - 1∙10-4 mol/L of metronidazole was measured using DCV and DPV at p-AgSA-CE with reached limits of quantification (LQs) 2∙10-6 mol/L and 4∙10-6 mol/L for DCV and DPV, respectively. For comparison of used voltammetric techniques with supplemental analytical method, the concentration range 2∙10-6 - 1∙10-4 mol/L of metronidazole...
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National Repository of Grey Literature : 12 records found   previous11 - 12  jump to record:
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