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	Voltage clamp analysis of ajmaline-induced block of potassium currents in ventricular myocytes Bahníková, M. ; Matějovič, P. ; Pásek, Michal ; Šimurdová, M. ; Šimurda, J. This study was aimed to analyze the effects of the antiarrhythmic drug ajmaline (a known inhibitor of the fast sodium current INa) on the potassium currents, namely the transient outward current (Ito) and the current measured at the end of a depolarizing pulse (IK) in rat ventricular myocytes. Both currents were inhibited in concentration- and voltage-dependent manner. However, the effects were frequency-independent. Úplný záznam
	Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells under low [K+]e Pásek, Michal ; Christé, G. ; Šimurda, J. In this work, we explored quantitatively the effect of ion concentration changes in the restricted space of transverse-axial tubular system (TAT-system) on ventricular cell arrhythmogenesis under the conditions of low extracellular potassium concentration ([K+]e). The simulations were performed on a model that integrates the quantitative description of electrical activity of surface and tubular membrane with the quantitative description of dynamic changes of intracellular ion concentrations. The results predict that the TAT-system plays a significant protecting role in cellular arrhythmogenesis that arises from the enhancement of potassium concentration gradient between tubular and extracellular spaces at low level of [K+]e. Úplný záznam
	Quantitative modelling of effect of transverse-axial tubular system on electrical activity of cardiac cells: development of model Pásek, Michal ; Christé, G. ; Šimurda, J. The transverse-axial tubular system (TAT-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many recent experimental works, it could have a significant effect on cardiac cell function induced by the accumulation or the depletion of ions in restricted tubular space. In our previous work [27], the basic properties of TAT-system were formulated and preliminary simulations characterizing its effect on cellular electrical activity realised. In this article, we describe the design of a more complex model of ventricular myocyte based mostly on data from guinea pig. The model integrates the description of electrical activity of surface and tubular membranes with the detailed description of mechanisms controlling the intracellular and tubular ion concentrations. Úplný záznam
	The role of transverse-axial tubular system in ventricular cardiac cell arrhythmogenesis: A simulation study Pásek, Michal ; Christé, G. ; Šimurda, J. A mathematical model of electrical activity of ventricular cardiac cell including a quantitative description of the transverse-axial tubular system (TAT-system) function is presented. The results of model simulations indicated that the TAT-system can play a role in arrhythmogenesis. Under different conditions the effect can be adverse or protective against initiations of ectopic arrhythmias. Úplný záznam
	Effect of modulation of ionic channel conductivities on restitution processes in cardiac cells (Computer modelling) Pásek, Michal ; Šlichta, J. The restitution properties of cardiac action potential were shown to be important determinants of stability of reentrant arrhythmias. The restitution hypothesis states that steeply sloped restitution curves (relations between action potential duration and preceding diastolic interval) induce unstable wave propagation that results in wave break, the event that leads to fibrillation. In this contribution we try to explore the effect of modulation of membrane channel conductuvities on electrical restitu**n curves by means of computer modelling. Úplný záznam
	The quantitative exploration of refractory period in human atrial cells Brožková, K. ; Pásek, Michal ; Šlichta, J. Refrakterní fáze srdečních buněk hraje významnou roli v procesu potlačení srdečních arytmií. Cílem této práce je vyšetřit refrakterní vlastnosti lidské síňové buňky prostřednictvím výpočtového modelování. Úplný záznam
	Computer modelling of effect of transversal tubules on excitation - contraction coupling in cardiac cells (Basic study) Pásek, Michal ; Christé, G. ; Šimurda, J. The transverse tubular system (T-system) of cardiac muscle is a structure that allows rapid propagation of excitation into the cell interior. As suggested in many resent experimental works it could have a significant effect on cardiac cell function in **ed by the accumulation or the depletion of ions in restricted tubular space. The aim of our work was to design a mathematical model of electrical activity of cardiac cell including a quantitative description of T-system function and to explore the phy Úplný záznam
	Simulace účinků blokády membránových kanálů na potlačení srdečních arytmií Pásek, Michal Předmětem práce je výpočtové modelování účinků blokády membránových kanálů propafenonem a 4-aminopyridinem na elektrickou aktivitu srdečních buněk. Úplný záznam
	Mathematical modelling of cardiac cell contraction Šlichta, J. ; Pásek, Michal This paper contains a proposal of model of cardiac cell contraction, which describes the processes leading to interaction of contractile proteins actin and myosin. Based on model published by D. A. Smith [4] a J. Neumann [1] a five-state model was created that is described by means of nine nonlinear differential equations Úplný záznam
	Matematický model interakce 4-aminopyridinu s draslíkovými kanály 3 Pásek, Michal ; Šimurda, J. Úplný záznam

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