National Repository of Grey Literature 6 records found  Search took 0.01 seconds. 
Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds
Otmar, Miroslav ; Masojídková, Milena ; Votruba, Ivan ; Holý, Antonín
2,6-Diamino-9-benzyl-9-deazapurine and 9-benzyl-2,6-bis(benzylamino)-9-deazapurine were synthesized by reductive cyclization of the corresponding 6-cyanomethyl-5-nitropyrimidines. Both compounds exhibit cytostatic activity in human T-lymphoblastoid CCRF-CEM cells.
Covalently linked purine dimers or trimers and purine-pyrimidine conjugates - analogues of nucleobase-pairs or triplets
Hocek, Michal ; Dvořák, D. ; Havelková, M.
Covalent analogues of pairs and triplets of nucleobases consisting of purine dimers and trimers and purine-pyrimidine conjugates connected by various types of carbon-linkers (acetylene, diacetylene, vinylene, ethylene, phenylene, benzenetriyl) are described.
Synthetic approaches to "opened-ring" acyclic nucleoside phosphonates - novel type of antivirals
Holý, Antonín
Diverse synthetic approaches to "opened-ring" acyclic nucleoside phosphonates - novel type of antivirals are described.
From nucleoside phosphonic acids to modified oligonucleotides
Rosenberg, Ivan ; Endová, Magdalena ; Králíková, Šárka ; Liboska, Radek ; Rejman, Dominik ; Točík, Zdeněk
A number of new isopolar phosphonate nucleotide analogues were prepared and a large set of oligonucleotides containing structurally diverse modification internucleotide linkages could be created.
Isosteric phosphonate mono-and oligonucleotides originating from 4',5'-didehydronucleoside precursors: some synthetic possibilities and limitations
Točík, Zdeněk ; Liboska, Radek ; Barvík, I. ; Buděšínský, Miloš ; Masojídková, Milena ; Kavenová, Ivana ; Rosenberg, Ivan
The work deals with aspects of synthesis and properties of isosteric phosphonate analogs of 5'-monophosphates and with structure-properties relationship of the related oligothymidylates.
Chemistry of Nucleic Acid Components. 12th Symposium
Točík, Zdeněk ; Hocek, Michal
In keeping with the main goals of the well-established series, the main topics of the XII NAC symposium covered the synthesis, transformations, physical chemistry, and biological activity of nucleosides, nucleotides and oligonucleotides as well as the aspects of their molecular biology in the broader sense.

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