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Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II
Pásek, Michal ; Christé, G. ; Šimurda, J.
In this work, we present a new version of cardiac ventricular cell model incorporating the transverse - axial tubular system. The improvements include reformulated description of L-type Ca2+ channel, of Ca2+ induced Ca2+ release from sarcoplasmic reticulum, of intracellular Ca2+ buffering and incorporation of potassium currents Ito, IK(Na) and IK(ATP). In comparison with the previous model (Pásek et al., 2002), the steady state simulations revealed more profound changes of tubular ionic concentration (12.8 % for Ca2+ and 4.7 % for K+ at 1 Hz). The refined model will be used for more exact quantitative exploration of the effect of transverse - axial tubular system on cellular electrical activity and excitation - contraction coupling.
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Simulation of resitance curves using Gurson plasticity model
Korouš, Jan ; Zemánková, Jaroslava
The concept of J-R curves is well established in structure assessment.However, the shape of J-R curves is influenced by constraint effectssignificantly. Such phenomena can be modelled using micromechanicalmodels of plasticity.The paper presents simulation of J-R curves usingthe complete Gurson model of plasticity, which was implemented into thefinite element system WARP3D.
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