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Synthesis and evaluation of potential antimicrobial drugs
Pflégr, Václav
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Organic and Bioorganic Chemistry Doctoral Degree Program Bioorganic Chemistry Candidate: Mgr. Václav Pflégr Supervisor: doc. PharmDr. Mgr. Martin Krátký, Ph.D. Title of Doctoral Thesis: Synthesis and evaluation of potential antimicrobial drugs The dissertation thesis reports some results achieved within the framework of a doctoral project dealing with the synthesis and evaluation of potential antimicrobial drugs. The main goal was to obtain new derivatives of isoniazid and its analogues acting against Mycobacterium tuberculosis and non-tuberculous mycobacteria, optimally including resistant strains. A partial aim was the preparation of peptide carriers for antituberculosis drugs, which, in addition to the development of new molecules, is another promising direction for the development of new therapeutic strategies against tuberculosis. The theoretical part of the dissertation overviews the issue of tuberculosis. The aetiology of the disease, the morphology of the cell wall of mycobacteria and selected epidemiological data are presented there. The treatment and characteristics of clinically used drugs are described in detail, this chapter is followed by a brief research review of promising clinically evaluated...
Synthesis and evaluation of potential antimicrobial drugs
Pflégr, Václav ; Krátký, Martin (advisor) ; Doležal, Martin (referee) ; Brulíková, Lucie (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Organic and Bioorganic Chemistry Doctoral Degree Program Bioorganic Chemistry Candidate: Mgr. Václav Pflégr Supervisor: doc. PharmDr. Mgr. Martin Krátký, Ph.D. Title of Doctoral Thesis: Synthesis and evaluation of potential antimicrobial drugs The dissertation thesis reports some results achieved within the framework of a doctoral project dealing with the synthesis and evaluation of potential antimicrobial drugs. The main goal was to obtain new derivatives of isoniazid and its analogues acting against Mycobacterium tuberculosis and non-tuberculous mycobacteria, optimally including resistant strains. A partial aim was the preparation of peptide carriers for antituberculosis drugs, which, in addition to the development of new molecules, is another promising direction for the development of new therapeutic strategies against tuberculosis. The theoretical part of the dissertation overviews the issue of tuberculosis. The aetiology of the disease, the morphology of the cell wall of mycobacteria and selected epidemiological data are presented there. The treatment and characteristics of clinically used drugs are described in detail, this chapter is followed by a brief research review of promising clinically evaluated...

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