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3D-bioprinted Gelatin/Alginate loaded with Carbon Nanotubes for tissue engineering application
Partovi Nasr, Minoo ; Zumberg, Inna ; Chmelíková, Larisa ; Fohlerová, Zdenka ; Provazník, Valentine
The objective of utilizing 3D-bioprinted Gelatin/Alginate loaded with Carbon Nanotubes (CNTs) in tissue engineering applications is to create scaffolds that closely mimic the natural extracellular matrix (ECM), thereby enhancing cell growth, proliferation, and differentiation. Gelatin and Alginate, both biocompatible materials, have been widely researched for their potential in bioprinting due to their similarity to the ECM, offering a conducive environment for cell encapsulation and tissue regeneration. The addition of CNTs to these hydrogels significantly improves the mechanical properties and stability of the scaffolds, making them more suitable for supporting tissue development. CNTs, known for their unique properties such as high tensile strength and electrical conductivity, contribute to the development of scaffolds that not only support mechanical stability but also can influence cellular behavior and tissue formation. This integration aims at enhancing the functionality of 3D-bioprinted scaffolds, enabling them to better support the formation and maturation of engineered tissues. Furthermore, the electrical conductivity of CNTs-loaded scaffolds can be exploited to stimulate electrical activity in tissues, such as cardiac and neural tissues, promoting organized tissue development and functionality. The strategic combination of Gelatin/Alginate with CNTs in 3D bioprinting offers a promising approach to tissue engineering, aiming to address the critical challenge of replicating the complex structure and function of natural tissues. This innovative methodology not only enhances the mechanical and structural properties of the scaffolds but also introduces new possibilities in tissue engineering through the electrical stimulation of tissues, paving the way for the creation of more complex and functional tissue constructs.
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