National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Interakce viru klíšťové encefalitidy s cytoskeletem hostitelských buněk
This thesis is focused on the role of host cytoskeleton, primarily microtubules and microfilaments, during tick-borne encephalitis virus infection in human neuroblastoma cell line SK-N-SH and tick cell line IRE/CTVM19. The importance of cytoskeletal integrity and dynamics to the viral replication cycle were examined using specific chemical inhibitors showing the virus utilizes studied structures in both cell lines. Immunofluorescence microscopy revealed structural changes in the actin cytoskeleton during late infection in SK-N-SH cells. Moreover, differences in expression of cytoskeleton-associated genes in both cell lines were compared. Several genes with up-regulated expression in SK-N-SH cells were identified during late infection.
Kontroverze prionové teorie
Prions are protein infectious particles in absence of nucleic acid, responsible for the fatal transmissible spongiform encephalopathies. This bachelor's thesis includes the characteristic of the infectious agent, the description of human and animal prion diseases, a historical development of the protein-only hypothesis and literary analysis of data about both protein-only theory and alternative hypotheses. Equally, this work points out the issue of the potential participation of cofactors in the process of the prion replication.

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