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Biopolymer particles based on polyhydroxybutyrate
Gregušková, Zuzana ; Zemanová, Jana (oponent) ; Přikryl, Radek (vedoucí práce)
This Bachelor´s thesis deals with preparation of abrasive particles from poly(3-hydroxybutyrate) and their optimization for cosmetics usage. It explores morphology of prepared particles and its effect on their abrasive ability. Moreover, it compares abrasive effectiveness of prepared particles with those commercially available. Several types of preparation methods of biopolymer particles such as milling, fibre spinning, pelletisation and solution preparation were carried out and optimized. Prepared particles were analysed using scanning electron microscopy. Semi-automatic system for testing of abrasiveness of prepared particles was made up from basic parts of 3D printing machine. This device was tested and calibrated using floral foam and sandpaper with different grades of granularity and used for comparison of abrasiveness of prepared particles. Mechanical response of particles under pressure was also investigated. It was found out that measured mechanical properties correlate with the data from abrasiveness test. Size and shape of particles, their morphology, mechanical properties and abrasiveness can be controlled depending on the preparation method used. Selected prepared and commercial abrasive particles were applied into prepared cosmetic foundations for peeling with the goal of sensory evaluation of abrasive effectiveness of prepared particles.
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Microfibers based on polyhydroxybutyrate for medical applications
Gregušková, Zuzana ; Obruča, Stanislav (oponent) ; Přikryl, Radek (vedoucí práce)
Master’s thesis targets microfibers based on biopolymer poly(3-hydroxybutyrate) and their use in medical applications. The theoretical part deals with a study of the microfibers creation process using the technology of centrifugal spinning, its kinetics and factors influencing the creation and properties of prepared microfibres. Subsequently, the theoretical part orientates on a short overview of biopolymers used in the technology, characterization of material poly(3-hydroxybutyrate). It also presents a proposal of a potential target application of the microfibres. The experimental part concentrates on microfibers preparation from the mentioned poly(3-hydroxybutyrate). Several parameters leading to better spinnability of the material are tracked and optimized. The practical part is extended by modifying the polymer solution by adding other biopolymers and plasticizers and producing microfibres from the polymer mixture thus treated. Attention is also paid to the optimization of process parameters. Moreover, the prepared microfibres are analyzed and characterized by several methods and compared to develop a suitable alternative to currently used substrates for cell growth in 3D.
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Biopolymer particles based on polyhydroxybutyrate
Gregušková, Zuzana ; Zemanová, Jana (oponent) ; Přikryl, Radek (vedoucí práce)
This Bachelor´s thesis deals with preparation of abrasive particles from poly(3-hydroxybutyrate) and their optimization for cosmetics usage. It explores morphology of prepared particles and its effect on their abrasive ability. Moreover, it compares abrasive effectiveness of prepared particles with those commercially available. Several types of preparation methods of biopolymer particles such as milling, fibre spinning, pelletisation and solution preparation were carried out and optimized. Prepared particles were analysed using scanning electron microscopy. Semi-automatic system for testing of abrasiveness of prepared particles was made up from basic parts of 3D printing machine. This device was tested and calibrated using floral foam and sandpaper with different grades of granularity and used for comparison of abrasiveness of prepared particles. Mechanical response of particles under pressure was also investigated. It was found out that measured mechanical properties correlate with the data from abrasiveness test. Size and shape of particles, their morphology, mechanical properties and abrasiveness can be controlled depending on the preparation method used. Selected prepared and commercial abrasive particles were applied into prepared cosmetic foundations for peeling with the goal of sensory evaluation of abrasive effectiveness of prepared particles.
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Microfibers based on polyhydroxybutyrate for medical applications
Gregušková, Zuzana ; Obruča, Stanislav (oponent) ; Přikryl, Radek (vedoucí práce)
Master’s thesis targets microfibers based on biopolymer poly(3-hydroxybutyrate) and their use in medical applications. The theoretical part deals with a study of the microfibers creation process using the technology of centrifugal spinning, its kinetics and factors influencing the creation and properties of prepared microfibres. Subsequently, the theoretical part orientates on a short overview of biopolymers used in the technology, characterization of material poly(3-hydroxybutyrate). It also presents a proposal of a potential target application of the microfibres. The experimental part concentrates on microfibers preparation from the mentioned poly(3-hydroxybutyrate). Several parameters leading to better spinnability of the material are tracked and optimized. The practical part is extended by modifying the polymer solution by adding other biopolymers and plasticizers and producing microfibres from the polymer mixture thus treated. Attention is also paid to the optimization of process parameters. Moreover, the prepared microfibres are analyzed and characterized by several methods and compared to develop a suitable alternative to currently used substrates for cell growth in 3D.
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