|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
|
Design and Synthesis of Helicene like Molecules
Bernard, Martin ; Sýkora, Jan ; Storch, Jan
Azahelicenes are unique inherently chiral three-dimensional aromatic compounds with high potential in homogenous assymetric catalysis. Their synthesis has many drawbacks and cannot be done in multigram scale so far. Recently, we have developed a route to new type of helicene-like molecules II. Multigram-scale synthesis of model compound where two benzene rings in [6]helicene skeleton are replaced by cyclopentadiene rings was accomplished in three steps. Such molecules have helical structure similar to helicenes, however, lower racemization barrier. Appropriately modified aza-analogues could be suitable catalysts for asymmetric reactions. Therefore, our synthetic approach leading to these compounds will be discussed.
Plný tet: 20120415230504 -  PDF
Plný text: content.csg - PDF
|
host ::
RSS.