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Regulation of the regular distribution of body covering structures
Zbirovský, Richard ; Soukup, Vladimír (advisor) ; Brejcha, Jindřich (referee)
5 Abstract Vertebrates are characterised by a great diversity of integumentary appendages, such as scales, feathers or hairs, or modifications derived from them. These organs tend to be distributed individually and evenly across the body surface, and the degree of regularity of their organisation may vary between species. The regulation of their formation and regular distribution is determined by epithelial-mesenchymal interactions. Signaling pathways are key components of these interactions, and molecular morphogens such as BMPs, Wnts, FGFs and Shh are their frequent participants. Many mathematical models have been proposed in an attempt to explain the relationships between those morphogens, which lead to the orderly spacing of integumentary appendages, during the process that is also known as patterning. Recently, however, the Turing reaction-diffusion model, consisting of the interplay between activators and inhibitors to achieve a self-organizing, repetitive patterning, has come to the fore again. The aim of this Bachelor thesis is to further explore the role of the Turing mechanism in the regulation and regularity of the distribution of body covering organs. Keywords: vertebrates, Turing, reaction-diffusion mechanism, patterning, feathers, hairs, scales, FGF, BMP, Shh, Wnt
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