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Effect of xanthohumol and 6-prenylnaringenin in the in vitro model of non-alcoholic fatty liver disease
Velecká, Eva ; Boušová, Iva (advisor) ; Zárybnický, Tomáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Eva Velecká Supervisor: doc. PharmDr. Iva Boušová, Ph.D. Consultant: Mgr. Michaela Šadibolová Title of diploma thesis: Effect of xanthohumol and 6-prenylnaringenin in the in vitro model of non-alcoholic fatty liver disease Non-alcoholic fatty liver disease (NAFLD) is a chronic disease characterized by the accumulation of triglycerides (TAG) in hepatocytes encompassing a wide spectrum of pathological states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and eventually progressing to cirrhosis and hepatocellular carcinoma. Xanthohumol (XH), a prenylflavonoid found in common hop (Humulus lupulus), is currently being studied as a potential drug for NAFLD therapy due to its described anti- steatotic, anti-inflammatory, anti-fibrotic, hypolipidemic and antioxidant effects. The aim of this thesis was to study the potential hepatoprotective effect of XH and 6-prenylnaringenin (6PN), a minor prenylflavonoid also found in common hop. For this purpose, a murine in vitro NAFLD model was used in which steatosis was induced by a lipogenic medium containing palmitic and oleic acid, fructose, citrate, and insulin in precision-cut liver slices (PCLS). Steatotic and non-steatotic PCLS...
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Sušení jako metoda konzervace masa a masných výrobků
Velecká, Eva
In the beginning of the thesis a reader will be apprised of a historical importance of meat to people, its consumption, chemical content and methods of its definition. There is a mention of a production process of durable heat-treated meat products, fermented meat products, raw hams and dry cured meat. I also focused on possible risks related to this type of products, legislation, specific products of several countries and their even-tual trade marks.
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