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Social-ecological linkages in the practice of Czech development cooperation
Suchá, Lenka ; Dušková, L. ; Seidlová, Aneta ; Schlossarek, M. ; Harmáček, J. ; Bubák, Š. ; Harmáčková, Veronika Zuzana
The Western Province of Zambia is one of the priority regions for Czech development cooperation. However, until now there has been a lack of comprehensive socio-ecological research carried out in this region, which would enable the actors of the Czech development cooperation to better work with the complex socio-ecological context within their projects. The research synthesis report presents in one place a comprehensive summary of the methodological approaches used and the results of their application. In this respect, the research synthesis report presents a unique perspective on socio-ecological linkages in the Western Province of Zambia. The research synthesis report also contains a simplified project methodology so that it can be used by Czech development actors themselves for planning and implementing development projects, if applicable. The research synthesis report also includes a summary of the main implications of the Coop4Wellbeing research for development practice, as well as a set of recommendations for Czech development donors.
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Adaptation to climate change: assessment of urban vulnerability to heatwaves and extreme heat
Suchá, Lenka ; Geletič, Jan ; Vaňo, Simeon ; Bašta, Petr ; Jančovič, M. ; Duchková, Helena
The methodology is focused on integrated modelling of climate change impacts on social-ecological systems in cities and on the methodological approach to vulnerability assessment of heatwaves and extreme heat at local and city scales. Recent approaches are often based on insufficient data where land use, land cover and distribution of population in space are considered as constant. This methodology then presents a complex approach to scenario building of future vulnerability of cities to heatwaves and extreme heat, that is based on data synthesis originating from spatial modelling and participatory processes. To this end, the methodology elaborates on the aspects of climate modelling, land use and land cover scenarios development and socio-demographic scenarios until the year 2050. The outcomes of the application of the methodology are a significant tool for urban adaptation planning in terms of adaptation measures allocation to the areas with recent and future sensibility to heat stress.
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A study on the activity of α-tomatine and newly synthetized derivatives of benzo[c]fluorene
Suchá, Lenka ; Tomšík, Pavel (advisor) ; Pejchal, Jaroslav (referee) ; Poučková, Pavla (referee)
Many of anticancer drugs are of natural origin. Plants from the Solanaceae family contain various steroidal glycoalkaloids that are toxic to cancer cells. The aim of the first part of this work was to evaluate the potential anticancer effect of α-tomatine - a steroidal glycoalkaloid from Solanaceae plant family. The second part of this work was focused on the anticancer research of newly synthetized derivatives of benzo[c]fluorene. Benfluron, one of the derivatives, was reported 30 years ago to have anticancer effects in vitro and in vivo almost. Tomatine inhibited the proliferation and viability of MCF-7 cells. In this cancer cell line treated with tomatine, no DNA damage, no changes in p53 and p21WAF1/CIP1 protein levels, neither the induction of apoptosis was demonstrated. However, the decrease in ATP levels was found. New synthetized derivatives of benfluron and dimefluron caused higher cytotoxic effect in the different cancer cell lines compared with their original compounds. On the other hand, these derivatives did not caused higher tumour growth inhibition when compared with their original compounds in in vivo studies. Benfluron and hydrazone of dimeflurone prolonged the survival of mice with inoculated solid form of Ehrlich tumour. In this work, we demontrated that tomatine did not induce apoptosis...
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A study on the activity of α-tomatine and newly synthetized derivatives of benzo[c]fluorene
Suchá, Lenka ; Tomšík, Pavel (advisor) ; Pejchal, Jaroslav (referee) ; Poučková, Pavla (referee)
Many of anticancer drugs are of natural origin. Plants from the Solanaceae family contain various steroidal glycoalkaloids that are toxic to cancer cells. The aim of the first part of this work was to evaluate the potential anticancer effect of α-tomatine - a steroidal glycoalkaloid from Solanaceae plant family. The second part of this work was focused on the anticancer research of newly synthetized derivatives of benzo[c]fluorene. Benfluron, one of the derivatives, was reported 30 years ago to have anticancer effects in vitro and in vivo almost. Tomatine inhibited the proliferation and viability of MCF-7 cells. In this cancer cell line treated with tomatine, no DNA damage, no changes in p53 and p21WAF1/CIP1 protein levels, neither the induction of apoptosis was demonstrated. However, the decrease in ATP levels was found. New synthetized derivatives of benfluron and dimefluron caused higher cytotoxic effect in the different cancer cell lines compared with their original compounds. On the other hand, these derivatives did not caused higher tumour growth inhibition when compared with their original compounds in in vivo studies. Benfluron and hydrazone of dimeflurone prolonged the survival of mice with inoculated solid form of Ehrlich tumour. In this work, we demontrated that tomatine did not induce apoptosis...
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Antimony determination by electrochemical hydride generation
Suchá, Lenka ; Hraníček, Jakub (advisor) ; Rychlovský, Petr (referee)
The aim of the presented bachelor thesis is to study the possibilities of the electrochemical hydride generation of volatile antimony hydride, using two newly constructed electrolytic cells. In this work, the properties of the cells were studied and consequently the basic characteristics of antimony determination obtained using new cells were compared with the chemical hydride generation method. At the beginning of the work, the relevant working parameters of both electrolytic cells were optimized. Under the optimal working conditions the calibration and other characteristics were carried out for antimony determination. Using the electrochemical hydride generation with thin-layer electrolytic cell and tubular cell and chemical hydride generation the sensitivity 3.40·10-3 l·μg-1 , 6.10·10-3 l·μg-1 and 2.10·10-3 l·μg-1 respectively were obtained. Finally, the influence of oxygen introduction in the different part of experimental setup was studied. This oxygen addition caused the characteristic and well-reproducible absorption peak. Key words Atomic absorption spectrometry, electrochemical generation of volatile compounds, quartz tube atomizer, thin-layer and tubular electrolytic cell, antimony
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Presentational capabilities of the nurses
VANÍČKOVÁ SUCHÁ, Lenka
The theoretic part of this thesis consists of two chapters. The first one deals with correct presentation, its preparation, data collecting and logical order of the information.The second part of the first chapter describes the system of lifelong education of nurses. Its first section provides basic information about the legislation of this system as well as about the adult education history. The next sub-chapters focus on individual types of education, which are included in the lifelong education of nurses. In order to research this area we proceeded from the assumed connection between the level of education and relationship to education and the quality of presentation skills. We selected a method of quantitative observation and a questionnaire.The objective of this thesis was to discover whether there was a connection between the level of presentation skills and the attitude of the nurses towards their education. The results of this research have shown that such a connection exists
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