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The diagnostic and prognostic ability of selected serum and urinary markers of prostate cancer
Do Carmo Silva, Joana Isabel ; Veselý, Štěpán (advisor) ; Čapoun, Otakar (referee) ; Fedorko, Michal (referee)
The diagnostic and prognostic ability of selected serum and urinary markers of prostate cancer Abstract Serum prostate specific antigen (PSA) is the only widely approved marker in prostate cancer (PC) diagnosis and follow up after treatment. Its role has remained controversial due to lack of specificity and the risk of overdiagnosis of insignificant PC. The aim of this work was to explore promising markers of PC and to improve current patient stratification to adjuvant treatment. Three main studies were performed using different media (urine and serum). The first study included the evaluation of Engrailed-2 (EN2) - a urinary marker of interest - in 90 patients with localized PC, 30 healthy controls, and 40 patients indicated for prostate biopsy. The second study evaluated 205 men with high-risk PC-features who underwent radical prostatectomy (RP) and were subject to a strict follow-up protocol of ultrasensitive PSA (UPSA) at close time intervals. The ability of particular measurements to predict biochemical recurrence (BCR) and thus the need for adjuvant therapy was assessed using the area under the curve (AUC) and a stratification model was created. The third study involved 128 patients who underwent RP. PSA and its serum isoforms normally used in the diagnostic context were evaluated both preoperatively...
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History and current state of recreational mathematics and its relation to serious mathematics
Bártlová, Tereza ; Pick, Luboš (advisor) ; Silva, Jorge Nuno (referee) ; Levy, Doron (referee)
Dissertation abstract The present thesis is devoted to the study of recreational mathematics, with a particular emphasis on its history, its relation to serious mathematics and its educational benefits. The thesis consists of five papers. In the first one we investigate the history of recreational mathematics. We focus on the development of mathematical problems throughout history, and we try to point out the people who had an important influence on the progress of recreational mathematics. The second article is dedicated to Edwin Abbott Abbott and his book called Flatland. It is one of the first popularizing books on geometry. In the third article we review one of the prominent personalities of recreational mathematics, Martin Gardner. The fourth article is in some sense a sequel to the third one. It deals with treachery of mathematical intuition and mathematical April Fool's hoaxes. The last article is devoted to the implementation recreational mathematics to education of students. 1
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History and current state of recreational mathematics and its relation to serious mathematics
Bártlová, Tereza ; Pick, Luboš (advisor) ; Silva, Jorge Nuno (referee) ; Levy, Doron (referee)
Dissertation abstract The present thesis is devoted to the study of recreational mathematics, with a particular emphasis on its history, its relation to serious mathematics and its educational benefits. The thesis consists of five papers. In the first one we investigate the history of recreational mathematics. We focus on the development of mathematical problems throughout history, and we try to point out the people who had an important influence on the progress of recreational mathematics. The second article is dedicated to Edwin Abbott Abbott and his book called Flatland. It is one of the first popularizing books on geometry. In the third article we review one of the prominent personalities of recreational mathematics, Martin Gardner. The fourth article is in some sense a sequel to the third one. It deals with treachery of mathematical intuition and mathematical April Fool's hoaxes. The last article is devoted to the implementation recreational mathematics to education of students. 1
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