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Immunogenic tumor cells as a source of tumor antigens for the treatment by active cellular immunotherapy DCVAC/OVCa in patients with ovarian cancer in I./II. phase of clinical trial.
Slavíčková, Lucie ; Jílek, Petr (advisor) ; Krejsek, Jan (referee)
Autor: Lucie Slavíčková Title: Immunogenic tumour cells as a source of tumour antigens for the treatment by active cellular immunotherapy DCVAC/OvCa in patients with ovarian cancer in phase II of clinical trial. Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Field of study: Pharmacy The utilization of the dendritic cell as an immunological modality for the cancer immunotherapy was enabled due to the finding of their major function in antigen presentation and also due to the induction of the primary immune response through the activation of the naive T-cells. The tumour cells from the cell lines killed by the high hydrostatic pressure are a suitable source of the antigens. This hydrostatic pressure induces an immunogenic cell death and provides an effective activation of immune responses. The objectives of this thesis are to describe the recent findings of the ovarian cancer immunotherapy. It is focused on dendritic cell based vaccine and on assessing the possible step for the optimization of the manufacturing protocol of this vaccine. Within the experimental part, I followed the kinetics of the immunogenic parameters in the tumour cells line SKOV3 of ovarian cancer which were treated by application of high hydrostatic pressure, the inducer of immunogenic cell...
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A Comparative Study of Two Late Baroque Sermons
SLAVÍČKOVÁ, Lucie
Main topic of this work is to analyze language and stylistic elements used in two sermons from baroque period dated 1709 and 1724. Both texts come from servites order library in Nove Hrady. In the first part, main traits of the baroque poetic art are thoroughly described with respect to preachership and most important baroque preachers. Either text is being compared from point of view of composition and stylistics, text structure as well as application of rhetorical elements and figurative language in particular composition parts is dealt with. Analysis of further language levels, especially with regard to phonetics, morfology and lexicology, is also included. No research in the field of syntax was made at this point. Principal aim of this work is to contribute to a deeper understanding of the usage of Czech language at the beginning of 18th century. It should influence the reader emotionally, be persuasive, form his way of thinking and help him to come up with new ideas.
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