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Contribution to the evaluation swelling mechanism of DL-lactic and glycolic acid oligoester
Rufferová, Lenka ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
In theoretical part this thesis deals with lactic acid polymers, their production, their characteristics, degradation and biological degradation. Also the use of these polymers in practice and the potential for their use in medicine are mentioned here. During seven days time the behavior of the DL-lactic acid oligoester and glycolic acid oligoester in aqueous environment was observed in the process of their degradation at the temperature of 37řC. The individual samples differed in their weight (50, 100, 150 and 250 mg) and in the length of the period of time, during which the behavior in the aqueous environment was observed. Three parameters were chosen as object of the observation: swelling degree, erosion degree and the acidity number. The results of the measurement were compared with the results of the observation of the behavior of the oligomer under identical conditions, but at the temperature of 7řC (those results were provided by my colleague Veronika Hašková). In some cases the results confirmed a correlation between the swelling degree and the acidity number in the course of the degradation of the oligoester. At the same time there was an evident difference in the behavior at the two different temperatures. The swelling and erosion of studied material proceeded at 37řC more intensively...
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Contribution to the evaluation swelling mechanism of DL-lactic and glycolic acid oligoester
Rufferová, Lenka ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
In theoretical part this thesis deals with lactic acid polymers, their production, their characteristics, degradation and biological degradation. Also the use of these polymers in practice and the potential for their use in medicine are mentioned here. During seven days time the behavior of the DL-lactic acid oligoester and glycolic acid oligoester in aqueous environment was observed in the process of their degradation at the temperature of 37řC. The individual samples differed in their weight (50, 100, 150 and 250 mg) and in the length of the period of time, during which the behavior in the aqueous environment was observed. Three parameters were chosen as object of the observation: swelling degree, erosion degree and the acidity number. The results of the measurement were compared with the results of the observation of the behavior of the oligomer under identical conditions, but at the temperature of 7řC (those results were provided by my colleague Veronika Hašková). In some cases the results confirmed a correlation between the swelling degree and the acidity number in the course of the degradation of the oligoester. At the same time there was an evident difference in the behavior at the two different temperatures. The swelling and erosion of studied material proceeded at 37řC more intensively...
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