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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
The evaluation of senescence markers in the H9c2 cell line after cobalt exposure
 Rottenbornová, Lucie ; Jirkovský, Eduard (advisor) ; Hrubša, Marcel (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Lucie Rottenbornová Supervisor: PharmDr. Eduard Jirkovský, Ph.D. Title of diploma thesis: The evaluation of senescence markers in the H9c2 cell line after cobalt exposure Introduction and aim: Cellular senescence is the response of a cell to a physiological or stressful stimulus. Cobalt is an element that simulates hypoxia under normoxic conditions through hypoxia-inducible factors. One of the factors that can induce cellular senescence is hypoxia. The aim of the work was to evaluate p16INK4a and Ki67 proteins as markers of cell senescence in an H9c2 cell line after exposure to CoCl2. Methods: Cytotoxicity was measured using the MTT assay on the H9c2 cell line after 24 and 48 hours of exposure to CoCl2. Subsequently, relative gene expression of genes associated with hypoxia (HIF1α and BNIP3) and senescence (p16INK4a and Ki67) in H9c2 after exposure to cobalt was investigated using the RT-PCR method. Results: Exposure of H9c2 cells to CoCl2 induced dose- and time-dependent toxicity. After a 24-hour exposure, CoCl2 toxicity was not observed up to a concentration of 100 μM, the IC50 value was 500.5 μM. After 48 hours of exposure, higher toxicity was observed already at 100 μM concentration and...
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The Tendencies in the Formation of Gender-marked Nouns
 ROTTENBORNOVÁ, Lucie
The aim of the present thesis is to provide description and analysis of the tendencies of gender-marked nouns denoting occupational titles in English. The first part focuses on the ways English language forms gender-specific terms and where gender marking is still relevant. This part deals with detailed analysis of word-formation processes, particularly with lexicalized compounds and suffixation phrases. The second part presents results based on search engine Google N-Gram Viewer which operates with the Google Books database. It gives frequency of masculine and feminine occurrences of competitive forms where not lexicalized compounds are concerned. The thesis is complemented with tables, figures and case studies.
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