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Control of DNA replication mediated by the ubiquitin-proteasome system
Kolumpek, Lukáš ; Čermák, Lukáš (advisor) ; Polášek-Sedláčková, Hana (referee)
The ubiquitin-proteasome system is an essential cellular instrument that provides timely degradation of specific protein substrates. This thesis examines its role in the regulation of DNA replication with emphasis on human cells, while thoroughly exploring DNA replication, with respect to its position in the cell cycle, and the ubiquitin-proteasome system.

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