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Deposition and diagnostics of plasmachemical prepared thin polymer layers based on 2-methyl-2-oxazoline
Podzemná, Daniela ; Slavíček, Pavel (referee) ; Mazánková, Věra (advisor)
The deposition of thin polymer layers, which are antibacterial and cytocompatible at the same time, is one of the solutions to prevent infection when using biomaterials in biomedical applications. The formation of layers based on plasma polymerization in the surface dielectric barrier discharge, which was used in the presented work, seems promising in terms of time and financial simplicity. When we use the plasma polymerization method, it should be possible to create a layer containing such functional groups that will have the ability to repel unwanted bacterial contamination. The analyte used in this work to form such layers is the monomer 2-methyl-2-oxazoline. Plasma polymerization of this substance produces polyoxazolines, which are known for their antibacterial and cytocompatible properties. Part of the work also deals with polytetrafluoroethylene, which in our case is substrate for deposition. The subject of the experimental work was the subsequent characterization of the layers using biological diagnostic methods, which were antibacterial tests and cytocompatibility tests in vitro. The physico-chemical properties of the layers were investigated using SEM, FT-IR and the surface free energy determination method. The experimental part also included the study of interactions of electrons and ions with molecules taking place in the plasma.
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