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Background innate reflex locomotion patterns of movement and ventilation in children patients with chronic respiratory diseases
Plešková, Jana ; Pohunek, Petr (advisor) ; Sedlák, Vratislav (referee) ; Homola, Lukáš (referee)
Reflex locomotion according to Professor Vojta (VRL) is based on the activation of complex motor patterns from certain defined positions with stimulation of the so-called trigger zones, located on the human's body. It is primarily used in patients with neurological deficits; however, it is currently also being used in internal medicine. It has been reported that VRL can indirectly affect breathing, however its use in paediatric patients with chronic respiratory disease has not yet been investigated. As part of this theses, a randomized controlled single-centre intervention study was conducted. Its aim was to evaluate the short-term effects of VRL on lung function in paediatric patients with cystic fibrosis (CF) with normal baseline spirometry. The effect of a 30minute VRL intervention was compared in a crossover design with the effect of positioning (without stimulation of trigger zones). The primary outcome was the change in global ventilation inhomogeneity, assessed by lung clearance index (LCI2.5) derived from nitrogen multiple breath washout test. Secondary outcomes included changes in regional ventilation inhomogeneity (indices of acinar [Sacin*Vt] and conductive airways [Scond*Vt] inhomogeneity) and spirometric parameters (inspiratory capacity, forced vital capacity, and forced expiratory...
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Evaluation of effect of mobile application CF Hero on compliance of inhalation treatment and respiratory physiotherapy of pediatric and juvenile patients with cystic fibrosis
Jirásek, Martin ; Plešková, Jana (advisor) ; Pokorný, Jan (referee)
This diploma thesis deals with the adherence to inhaled treatment, its measurement, telemedicine and telerehabilitation and the possible use of the CF Hero mobile app in paediatric patients with cystic fibrosis. In the theoretical part, it presents knowledge about cystic fibrosis, adherence to treatment in patients with cystic fibrosis and possibilities of its measurement, telemedicine and telerehabilitation. The practical part describes the CF Hero mobile app, which has been the target of measurements on several patients. At the same time, a questionnaire was developed focusing on satisfaction with the use of this mobile application. Methods: The practical part was conducted as a multicentre prospective cross-over study investigating the effect of the CF Hero mobile app on adherence to inhaled treatment, respiratory quality of life and chest excursion The evaluation was conducted over a 6-month period, with the primary objective being to measure the amount of exhaled solution relative to the prescribed amount. Simultaneously, each patient underwent 3 identical examinations. These examinations included spirometric testing (FEV1, FVC, MEF50), measurement of chest excursion (axillary, mesosternal, xiphoid) and quality of life assessment using the CFQ-R questionnaire. It also included measurement of...
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Impact of home- based physical training programme on values of pulmonary function test and aerobic exercise capacity of children with cystic fibrosis
Štefanová, Petra ; Plešková, Jana (advisor) ; Smolíková, Libuše (referee)
This diploma thesis takes interest in the issue of physical activities of children with cystic fibrosis, in possible impacts of such activities on clinical condition, in options of prescription of physical activities based on the actual clinical state of a person with cystic fibrosis, and in options of objectification of changes induced by an exercise programme. The theoretic part of this thesis summarizes the current findings about cystic fibrosis, therapy and physical activities in the context of prognosis of patients with cystic fibrosis. In experimental part, we performed examinations on few participants, who were willing to perform a home-based exercise programme. Also, we made a short exploratory questionnaire focused on the attitude of children with cystic fibrosis towards physical exercises. Methodology: We observed the evolution of maximal oxygen uptake VO2max, forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and of the scores of 1- minute sit-to-stand test (1-MSTST). All the measurements were performed before and after 12- weeks long exercise intervention. The inclusion criteria were diagnosis of cystic fibrosis, age over 10 years, FEV1 over 60 % predicted and no present signs of an acute exacerbation. Participants were assessed by spirometry examination,...
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