|
|
Comparison of efficacy of acetylcholinesterase inhibitors tacrine, rivastigmine and donepezil for the treatment of cognitive disorders induced by 3-quinuclidinyl benzylate in rat
Pavlíčková, Stela ; Vopršalová, Marie (advisor) ; Herink, Josef (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Mgr. Stela Pavlíčková Supervisor: PharmDr.Marie Vopršálová, CSc. Supervisor specialist: RNDr. Jan Misík, Ph.D. Title of rigorosa thesis: Comparison of efficacy of acetylcholinesterase inhibitors tacrine, rivastigmine and donepezil for the treatment of cognitive disorders induced by 3-quinuclidinyl benzylate in rat Alzheimer's disease is a severe neurodegenerative disorder connected with neuronal death, brain tissue loss and functional disruption of the cholinergic system. Pathophysiological changes are manifested especially as deterioration of memory and other cognitive functions. Current treatment consists mainly of pro-cognitive drugs - acetylcholinesterase inhibitors (previously - tacrine, today - donepezil, rivastigmine and galantamine) and NMDA (N-methyl-D- aspartate) antagonist memantine which can delay the disease progression. The aim of this study was to evaluate the therapeutic effect of three selected acetylcholinesterase inhibitors - tacrine, rivastigmine and donapezil on pharmacologically induced cognitive disorder in rats. As an amnesic drug, 3-quinuclidinyl benzilate was used and the effect of selected inhibitors was investigated using two different behavioral methods -...
|
|
|
Pain therapy with focus on pacients with oncological disease
Pavlíčková, Stela ; Melicharová, Ludmila (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Stela Pavlíčková Supervisor: PharmDr. Ludmila Melicharová Title of diploma thesis: Pain therapy with focus on pacients with oncological disease Pain therapy is a part of the oncological illnesses complex treatment. This therapy doesn't solve the cause of cancer, but significantly increase patient's quality of life during oncological treatment, even in the terminal stage. The main target of this work is to give basic information about pain treatment, focusing on the oncological pain, and elaborate a review of pharmacological groups and individual substances most used in oncological pain treatment. Basic pillar of the cancer pain treatment is pharmacotherapy, which goes out of the WHO three-grade analgesic ladder. Basic therapy is made of nonopioid analgesics. In case that they aren't enough, we can add weak opioids, which can be replaced by strong opioids afterwards. Analgesics are usually used repeatedly and often in combinations. Dosage interval depends on pharmacological properties, dosage form and patient condition. Well controlled pain phases are usually interrupted by very strong, cruel pain episodes, which are called break-through pain. Very strong pain, fully or partially...
|
|
|
Comparison of efficacy of acetylcholinesterase inhibitors tacrine, rivastigmine and donepezil for the treatment of cognitive disorders induced by 3-quinuclidinyl benzylate in rat
Pavlíčková, Stela ; Vopršalová, Marie (advisor) ; Herink, Josef (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Mgr. Stela Pavlíčková Supervisor: PharmDr.Marie Vopršálová, CSc. Supervisor specialist: RNDr. Jan Misík, Ph.D. Title of rigorosa thesis: Comparison of efficacy of acetylcholinesterase inhibitors tacrine, rivastigmine and donepezil for the treatment of cognitive disorders induced by 3-quinuclidinyl benzylate in rat Alzheimer's disease is a severe neurodegenerative disorder connected with neuronal death, brain tissue loss and functional disruption of the cholinergic system. Pathophysiological changes are manifested especially as deterioration of memory and other cognitive functions. Current treatment consists mainly of pro-cognitive drugs - acetylcholinesterase inhibitors (previously - tacrine, today - donepezil, rivastigmine and galantamine) and NMDA (N-methyl-D- aspartate) antagonist memantine which can delay the disease progression. The aim of this study was to evaluate the therapeutic effect of three selected acetylcholinesterase inhibitors - tacrine, rivastigmine and donapezil on pharmacologically induced cognitive disorder in rats. As an amnesic drug, 3-quinuclidinyl benzilate was used and the effect of selected inhibitors was investigated using two different behavioral methods -...
|
|
|
Pain therapy with focus on pacients with oncological disease
Pavlíčková, Stela ; Melicharová, Ludmila (advisor) ; Vopršalová, Marie (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Stela Pavlíčková Supervisor: PharmDr. Ludmila Melicharová Title of diploma thesis: Pain therapy with focus on pacients with oncological disease Pain therapy is a part of the oncological illnesses complex treatment. This therapy doesn't solve the cause of cancer, but significantly increase patient's quality of life during oncological treatment, even in the terminal stage. The main target of this work is to give basic information about pain treatment, focusing on the oncological pain, and elaborate a review of pharmacological groups and individual substances most used in oncological pain treatment. Basic pillar of the cancer pain treatment is pharmacotherapy, which goes out of the WHO three-grade analgesic ladder. Basic therapy is made of nonopioid analgesics. In case that they aren't enough, we can add weak opioids, which can be replaced by strong opioids afterwards. Analgesics are usually used repeatedly and often in combinations. Dosage interval depends on pharmacological properties, dosage form and patient condition. Well controlled pain phases are usually interrupted by very strong, cruel pain episodes, which are called break-through pain. Very strong pain, fully or partially...
|
guest ::
RSS feed.