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National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
Advances in diagnosis and therapy of cervical cancer
 Pasdiorová, Markéta ; Semecký, Vladimír (advisor) ; Nachtigal, Petr (referee)
Cervical cancer is the second most frequent cancerous disease presented in the statistical analysis of women in the world as well as in the Czech Republic and its incidence increases also in younger age groups. This serious disease is among other etiological factors induced by virus infection of human papillomavirus from the group of HPV. The presented thesis deals with current knowledge about the origin and progress of the cervical cancer, its prevention, diagnosis and effective treatment options. The practical part describes the diagnostic method which is gradually recommended to specify the diagnosis of the disease - the INNO-LIPA method which is based on reverse hybridization and used to determine the type of HPV. The thesis also includes the test results of the group of patients from clinical material of workplace Department of Molecular Genetics Laboratory CGB a.s. Ostrava that were diagnosed by the method.
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The study of bacterial microflora at patients with spontaneous early delivery.
 Pasdiorová, Markéta ; Hronek, Miloslav (advisor) ; Vrbacký, Filip (referee)
1. ABSTRACT Bc. Markéta Pasdiorová The study of bacterial microflora at patients with spontaneous early delivery Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Healthcare Bioanalytics - Specialist in Laboratory Methods Backround: Premature delivery and premature rupture of membranes have been associated with maternal genital tract infections or with altered vaginal microflora during pregnancy. This work discuses knowledge about vaginal microbiome, premature delivery and analysis options of vaginal microbiome using next-generation sequencing. The aim of the work was to evaluate the composition of the bacterial microflora at patients with spontaneous preterm delivery and compared with each other of vaginal and cervical samples. Methods: The study group consisted of 7 patients with diagnosed spontaneous preterm delivery. Samples were obtained on the basis of cooperation with the Department of Obstetrics and Gynecology of University Hospital Hradec Králové. The evaluation of the vaginal microbiome was performed by pyrosequencing method using Genome Sequencer FLX+. Results: We have observed all typical patterns of the vaginal microflora in the samples tested. The most frequent species were Lactobacillus crispatus/casei and L. iners, which belong to the four most dominant...
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Advances in diagnosis and therapy of cervical cancer
 Pasdiorová, Markéta ; Semecký, Vladimír (advisor) ; Nachtigal, Petr (referee)
Cervical cancer is the second most frequent cancerous disease presented in the statistical analysis of women in the world as well as in the Czech Republic and its incidence increases also in younger age groups. This serious disease is among other etiological factors induced by virus infection of human papillomavirus from the group of HPV. The presented thesis deals with current knowledge about the origin and progress of the cervical cancer, its prevention, diagnosis and effective treatment options. The practical part describes the diagnostic method which is gradually recommended to specify the diagnosis of the disease - the INNO-LIPA method which is based on reverse hybridization and used to determine the type of HPV. The thesis also includes the test results of the group of patients from clinical material of workplace Department of Molecular Genetics Laboratory CGB a.s. Ostrava that were diagnosed by the method.
Detailed record

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