National Repository of Grey Literature 5 records found  Search took 0.01 seconds. 
Nové virostatikum, 1-(S)-[3-hydroxy-(2-phosphonomethoxy)propyl]-5-azacytosin: estery a modifikované baze
Krečmerová, Marcela ; Holý, Antonín ; Pískala, Alois ; Andrei, G. ; Snoeck, R. ; Balzarini, J. ; De Clercq, E.
A series of 6-alkyl-HPMP-5azaC was synthesized using ammonia mediated ring-opening reaction of protected HPMP-5-azaC ester followed by condensation reaction with orthoesters and deprotection of ester groups. Introduction of long chain acyl groups to the N4-position was performed using reaction of some acyl chloride (e.g. behenoyl chloride) and appropriate ester of HPMP-5-azaC or its cyclic form.

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