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Nursing care of the patient with hypertension in outpatient department
Šamlotová, Jana ; Zvoníčková, Marie (advisor) ; Monhart, Václav (referee)
Ve své bakalářské práci předkládám případovou studii pacienta s nekorigovanou hypertenzí. Pacient byl objednán do ambulance na základě doporučení praktické lékařky. V klinické části popisuji patofyziologii vzniku vysokého krevního tlaku. Uvádím vyšetřovací metody, klasifikaci hypertenze a léčbu. Ve své práci se zaměřuji na primární hypertenzi v rámci ambulantní péče. Ošetřovatelskou část tvoří plán ošetřovatelské péče sestavený podle modelu Marjory Gordon, jeho realizace a hodnocení. Součástí ošetřovatelské části je edukace pacienta a prognóza.
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The influence of some factors on renal impairment in AA amyloidosis
Potyšová, Zuzana ; Ryšavá, Romana (advisor) ; Monhart, Václav (referee) ; Horák, Pavel (referee)
Introduction: Available data suggest an association between presence of secondary (AA) amyloidosis and MCP-1 (monocyte chemoatracttant protein-1) and MIP-1alpha (macrophage inflammatory protein-1 alpha) genes polymorphisms. Some studies have also shown an impact of polymorphisms in exon 3 of SAA 1 (serum amyloid A 1) gene on the incidence of AA amyloidosis in different populations. Methods: The incidence of single genotypes MCP-1, MIP-1alpha and SAA 1 genes was investigated. Serum levels of SAA, MCP-1 and MIP-1alpha were measured and potential relation between serum levels and genotypes were analyzed. All examinations were performed in patients with AA amyloidosis (43), rheumatoid arthritis (RA) without amyloidosis and healthy control group (100). Results: Significantly more frequent occurrence of 1.1/1.1 genotype in SAA 1 was recorded in AA amyloidosis group compared to RA group as well as in control group (p<0,001). No statistically significant differences in distribution of another genotypes were found. Distribution of neither 1.1/1.1 genotype nor another ones did not vary among RA group and control group. No significant difference in distribution of another examined genotypes was recorded among all three groups. Serum concentrations of SAA were statistically significantly higher in AA amyloidosis group...
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The role of endothelial progenitor cells in the pathogenesis of anti - neutrophil cytoplasmatic antibody - associated vasculitis
Závada, Jakub ; Tesař, Vladimír (advisor) ; Haluzík, Martin (referee) ; Monhart, Václav (referee)
Summary: Introduction: Circulating endothelial progenitor cells (EPC) may provide an endogenous repair mechanism to counteract ongoing endothelial damage. Antineutrophil cytoplasmic antibody - associated vasculitis (AAV) is an inflammatory disorder of small- to medium-sized vessels with relapsing/remitting progression and endothelial injury is a major feature of AAV. EPC thus may play and an important role in the pathogenesis of AAV, or serve as a useful marker for monitoring and/or prediction of outcomes in patients with AAV. Hypotheses: EPC number in patients with AAV could be altered. The decreased capacity for endothelial regeneration paralleled by low EPC numbers could increase the risk of relapse in patients with AAV. Patients and methods: We have measured EPC in healthy volunteers, patients with AAV, chronic kidney failure (CKD) and atherosclerosis by a colony-forming assay. We have investigated the relation between the numbers of EPC, clinical and laboratory characteristics of the patients, and long-term outcomes of patients with AAV. Results: Patients with AAV had a significantly lower number of EPC than healthy subjects, but not than patients with CKD or atherosclerosis. The cumulative relapse-free survival increased stepwise across three increasing baseline levels of endothelial progenitor cells....
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The influence of some factors on renal impairment in AA amyloidosis
Potyšová, Zuzana ; Ryšavá, Romana (advisor) ; Monhart, Václav (referee) ; Horák, Pavel (referee)
Introduction: Available data suggest an association between presence of secondary (AA) amyloidosis and MCP-1 (monocyte chemoatracttant protein-1) and MIP-1alpha (macrophage inflammatory protein-1 alpha) genes polymorphisms. Some studies have also shown an impact of polymorphisms in exon 3 of SAA 1 (serum amyloid A 1) gene on the incidence of AA amyloidosis in different populations. Methods: The incidence of single genotypes MCP-1, MIP-1alpha and SAA 1 genes was investigated. Serum levels of SAA, MCP-1 and MIP-1alpha were measured and potential relation between serum levels and genotypes were analyzed. All examinations were performed in patients with AA amyloidosis (43), rheumatoid arthritis (RA) without amyloidosis and healthy control group (100). Results: Significantly more frequent occurrence of 1.1/1.1 genotype in SAA 1 was recorded in AA amyloidosis group compared to RA group as well as in control group (p<0,001). No statistically significant differences in distribution of another genotypes were found. Distribution of neither 1.1/1.1 genotype nor another ones did not vary among RA group and control group. No significant difference in distribution of another examined genotypes was recorded among all three groups. Serum concentrations of SAA were statistically significantly higher in AA amyloidosis group...
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Nursing care of the patient with hypertension in outpatient department
Šamlotová, Jana ; Zvoníčková, Marie (advisor) ; Monhart, Václav (referee)
Ve své bakalářské práci předkládám případovou studii pacienta s nekorigovanou hypertenzí. Pacient byl objednán do ambulance na základě doporučení praktické lékařky. V klinické části popisuji patofyziologii vzniku vysokého krevního tlaku. Uvádím vyšetřovací metody, klasifikaci hypertenze a léčbu. Ve své práci se zaměřuji na primární hypertenzi v rámci ambulantní péče. Ošetřovatelskou část tvoří plán ošetřovatelské péče sestavený podle modelu Marjory Gordon, jeho realizace a hodnocení. Součástí ošetřovatelské části je edukace pacienta a prognóza.
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