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The importance of cell-free HPV DNA detection
Milt, Petr ; Saláková, Martina (advisor) ; Horníková, Lenka (referee)
Human papillomaviruses (HPV) are small, nonenveloped DNA viruses that are abundant in the population. They are sexually transmitted or spread by close contact with mucosa and skin. Papillomaviruses can cause lesions and warts on the skin and mucosa. In addition, high-risk HPV types, especially HPV 16 and 18, are associated with squamous cell carcinomas such as cervical cancer, oropharyngeal cancer and carcinomas of the vulva, anus, penis and vagina. Early detection and the right evaluation of the risk of recurrence are crucial for effective treatment. Cell-free DNA released from cells into body fluids has potential in cancer diagnosis. Cell-free circulating HPV DNA, in the blood of patients with HPV-associated cancers is a promising and highly sensitive biomarker, useful for monitoring treatment efficiency, early detection of the disease and estimation of recurrence risk. Key words: HPV, carcinogenesis, cfDNA, cfHPV DNA, significance of detection, cervical cancer, oropharyngeal cancer
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