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LabVIEW instrument control toolbox
Mazal, Ctibor ; Aboelhassan, Mustafa Osman Elrayah (referee) ; Blaha, Petr (advisor)
This diploma thesis is containing the description of the LabVIEW Instrument Control Toolbox project. Initial preparations like the development environment choosing process, as well as the instrument driver layer choice are present along with the project requirements. A signal approach to the instrument control is defined and described in detail. This thesis also contains the main project development in The National Instruments LabVIEW and at the end, a detailed description and user guidance for each developed and fully integrated toolbox module.
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Reactions of Alkenes Iniciated by Transition Metals Alkyls and Hydrides
Nečas, David ; Kotora, Martin (advisor) ; Jindřich, Jindřich (referee) ; Starý, Ivo (referee) ; Mazal, Ctibor (referee)
l0 5. Conclusion 1) The first and practical catalýic method for smooth deallylation of 2-substituted-2-allylmalonates to 2-substituted malonates via selective cleavage of the C-C bond under mild reaction conditions has been developed' The reaction seems to be general with respect to the transition-metal complexes; however, the comparison of Ru and Ni catalysts indicates considerable differences in their specific activity and selectiviý. Last but not least, the smooth deallylation offers an opportuniý to use the allyl group as an effective protective group for acidic hydrogen of malonic esters. 2) It has been shown that it is possible to re-route the course of the reaction from c{ bond cleavage (deallylation) to c{ bond formation (cyclization) in Ni hydride cataryzed, reactions by a change in the amount of organoaluminium. It proceeded in high yields even in cases where deallylation could compete with cyclization (e.g. diallylmalonate, etc.) in high selectiviý. In addition, generation of Ni hydride species in sinr provides an effective means for fast and selective cyclization of variously substituted 1,6- heptadienes to cyclopentanes. Moreover, it is possible exert certain level of control for the preferential formation of methylidene(methyl)cyclopentanes or cyclopentenes by the appropriate choice of thb...
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Chemical and Physical Properties of Single Molecules and Their Assemblies Adsorbed on Solid Surfaces
Houska, Václav ; Starý, Ivo (advisor) ; Mazal, Ctibor (referee) ; Církva, Vladimír (referee)
Interaction of organic molecules with solid surfaces represents a key area of physical-chemistry research. From heterogenous catalysis to OLED displays, in numerous such systems molecules interact on interfaces, and understanding their behavior is crucial for the correct operation of such applications. In this work, I focused on the study of large π-conjugated macrocycles based on dibenzo[5]helicenes with emphasis on their behavior on graphite surface. The chemical synthesis of the investigated macrocycles was initially impeded by a number of obstacles, particularly by their extremely low solubility. In this work, an efficient solubilization strategy based on the modification of the macrocycles with trityl groups was discovered, which effectively diminishes the intense intermolecular π-π interactions. This opened a path towards a subsequent study of the compound's properties. The attention was focused mainly on a trimer, which was successfully fully characterized, enabling further experiments. Since only a few tens of milligrams of the trimer was prepared, and some stereoisomers were isolated in only microscopic amounts, it was important to develop a suitable experimental methodology. These methods were successfully employed in the measurement of the isomerization kinetics, which allowed us to map...
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Synthesis of Purine - Amino Acid Conjugates
Čapek, Petr ; Hocek, Michal (advisor) ; Kotora, Martin (referee) ; Dvořák, Dalimil (referee) ; Mazal, Ctibor (referee)
4. Conclusions A simple and efficient approach to the synthesis of (purin-6-yl)alanines based on Negishi cross-coupling reactions of 6-iodopurines and iodozinc- alanines applicable to the synthesis of both racemic and optically pure compounds was developed. Though analogous reactions were used before for the synthesis of some simple aryl- or hetarylaranines, this was the first successful use in the functionalization ofprotected nucleobases and nucleosides. A practical method for synthesis of enantiomerically pure (purin-6_ yl)phenylalanines by palladium catalyzeď, copper mediated Stille cross-coupling reactions ofprotected 4-(trimethylstanyl)phenylalanines and 6-iodopurines was developed. This method was used in the synthesis of series of (purin_6_ yl)phenylalanines (bases and nucleosides) varying in substitution in position 9 of purine scaffold and in absolute configuration on o-carbon ofphenylalanine. The shaughnessy method for the Suzuki cross-coupling reactions in aqueous media was further optimized and applied to the single-step synthesis of novel optically pure (adenin-8-yl)phenylalanines and (purine_6_yl)phenyl_ alanines. wide tolerance of this methodology towards variety of functionalities and its applicability to 1abile systems was demonstrated particularly by the very first examples of couplings...
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Reactions of Alkenes Iniciated by Transition Metals Alkyls and Hydrides
Nečas, David ; Kotora, Martin (advisor) ; Jindřich, Jindřich (referee) ; Starý, Ivo (referee) ; Mazal, Ctibor (referee)
l0 5. Conclusion 1) The first and practical catalýic method for smooth deallylation of 2-substituted-2-allylmalonates to 2-substituted malonates via selective cleavage of the C-C bond under mild reaction conditions has been developed' The reaction seems to be general with respect to the transition-metal complexes; however, the comparison of Ru and Ni catalysts indicates considerable differences in their specific activity and selectiviý. Last but not least, the smooth deallylation offers an opportuniý to use the allyl group as an effective protective group for acidic hydrogen of malonic esters. 2) It has been shown that it is possible to re-route the course of the reaction from c{ bond cleavage (deallylation) to c{ bond formation (cyclization) in Ni hydride cataryzed, reactions by a change in the amount of organoaluminium. It proceeded in high yields even in cases where deallylation could compete with cyclization (e.g. diallylmalonate, etc.) in high selectiviý. In addition, generation of Ni hydride species in sinr provides an effective means for fast and selective cyclization of variously substituted 1,6- heptadienes to cyclopentanes. Moreover, it is possible exert certain level of control for the preferential formation of methylidene(methyl)cyclopentanes or cyclopentenes by the appropriate choice of thb...
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LabVIEW instrument control toolbox
Mazal, Ctibor ; Aboelhassan, Mustafa Osman Elrayah (referee) ; Blaha, Petr (advisor)
This diploma thesis is containing the description of the LabVIEW Instrument Control Toolbox project. Initial preparations like the development environment choosing process, as well as the instrument driver layer choice are present along with the project requirements. A signal approach to the instrument control is defined and described in detail. This thesis also contains the main project development in The National Instruments LabVIEW and at the end, a detailed description and user guidance for each developed and fully integrated toolbox module.
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