|
|
Antimicrobial effect of antidepressants. I.
Marečková, Helena ; Jílek, Petr (advisor) ; Vejsová, Marcela (referee)
1 Abstract Several years ago antimicrobial activity was describe for psychotropic drugs against wide groups of microorganisms. Recently it was found that one class of them, known as selective serotonin reuptake inhibitors (SSRI), has in vivo and in vitro antifungal activity. In this study the minimal inhibitory concentrations (MIC) of two SSRI (paroxetine and fluoxetine) against various strains of Candida spp. (Candida albicans, C. glabrata, C. krusei, C. lusitaniae, C. parapsilosis and C. tropicalis), Saccharomyces cerevisiae and Trichosporon beigelii using a broth microdilution test were investigated. The most susceptible fungal organism was Saccharomyces cerevisiae - fluoxetine (MIC 15,6µg/ml) and paroxetine (MIC 31,25µg/ml). In the second part of our study we tested combination of some antifungal agents (amphotericin B, fluconazole and flucytosine) with paroxetine and fluoxetine using checkerboard method. Activity was measured against two strains Candida albicans, one strain Saccharomyces cerevisiae and three auxotrophic strains Candida albicans (CA-SC, CA-BWOZ, CA-BWP), depended on uridine. For fluconazole testing we used six fluconazole-resistant strains Candida spp. in addition. The fractional inhibitory concentration (FIC) indexes ranged between 0,5 and 2,4 for the various combinations and various...
|
guest ::
RSS feed.