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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Localization of individual opioid receptor subtypes in CNS
 Lišháková, Michaela ; Hejnová, Lucie (advisor) ; Bendová, Zdeňka (referee)
In last decades, the research focused on opioid receptors has been intensively conducted in order to determine their role in various homeostatic functions, control of movement, neurotransmission and drug addiction. An important factor determining the pharmacologic role of opioid receptors is their distribution within the brain regions as well as at the cellular level. Over the past 40 years, a great deal of information concerning their distribution in the central nervous system has been collected, allowing us to determine their localization and mechanisms of their action. In general, results obtained from previous studies are in agreement. However, there are some inconsistencies that impede the accurate determination of receptor distribution and need to be clarified. This paper aims to summarize results of the previously published studies observing the localization of opioid receptors in the rat CNS. Emphasis is placed on the comparison of results obtained by all available methods.
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The role of logistics in the pharmaceutical industry
 Lišháková, Michaela ; Sato, Alexej (advisor) ; Búda, Martin (referee)
Bachelor thesis deals with the logistics of the supply chain in the pharmaceutical industry, while focusing on the wholesalers operating this sector in the Czech market. The introduction presents general requirements related to the storage and distribution of drugs, imposed by the regulatory authorities and pharmaceutical manufacturers. Subsequently, the thesis discusses recent events that have altered the nature of the industry globally as well as locally. The emphasis is placed on the transformation of relations between individual actors of the supply chain, which was caused by the increase of production of drugs in developing countries, the changing nature of pharmaceutical products and the fast technology development. Further, it describes the system of drug distribution in the domestic market and analyzes the positions and business strategies of the largest wholesale companies. Presented are arguments why another mergers and acquisitions are expected in the near future. The result of the analysis is a proposition of business strategy for chosen company that should contribute to maintaining its position in the Czech market.
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