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The issue of injuries in children
Kaczorová, Ľubomíra ; Tomová, Šárka (advisor) ; Kučera, Alexandr (referee)
The thesis "Paediatric Trauma" is divided in two main parts. Tbe theoretical part oť tbe thesis informs a reader about epidemiology and prevention oť paediatric trauma. Especialy bome environment as a risky ťactor in early chiJdhood and pre-schooJ age bas been mentioned in detail including prevention oftrauma in the above age group. The second, practical part, analysis result of research. This part inc1udes anonyrnous questionnaire applied in tbe above age groups. Group oť respondents consists of parents of cbildren in early cbildhood and pre-school age as well. The practical part is followed by discussion. Powered by TCPDF (www.tcpdf.org)
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Affecting the growth of a tumor on an experimental animal model
Kučera, Alexandr ; Škába, Richard (advisor) ; Eckschlager, Tomáš (referee) ; Havránek, Petr (referee) ; Kalous, Martin (referee)
In this study we present the models of preventive and therapeutic vaccination of sarcoma-bearing rats with dendritic cells that present tumor antigens from killed tumor cells. We present the characteristics of DCs-based vaccine and its capacity to induce antitumor immune response both in v vitro and in vivo. We show that preventive vaccination efficiently prevents the growth of tumors. On the other hand vaccination of rats with established tumors did not led to the eradication of tumors. Despite the induction of a vigorous immune response after administration of DCs-based vaccine and transient decrease in tumor progression, tumors eventually resumed their growth and animals vaccinated with DCs succumbed to cancer. In both settings, preventive and therapeutic, DCs-based vaccination induced a vigorous tumor specific T cells response. These results argue for the timing of cancer immunotherapy to the stages of low tumor load. Immunotherapy initiated at the stage of minimal residual disease, after reduction of tumor load by other modalities, will have much better chance to offer a clinical benefit to cancer patients than the immunotherapy at the stage of metastatic disease. Powered by TCPDF (www.tcpdf.org)
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The issue of injuries in children
Kaczorová, Ľubomíra ; Tomová, Šárka (advisor) ; Kučera, Alexandr (referee)
The thesis "Paediatric Trauma" is divided in two main parts. Tbe theoretical part oť tbe thesis informs a reader about epidemiology and prevention oť paediatric trauma. Especialy bome environment as a risky ťactor in early chiJdhood and pre-schooJ age bas been mentioned in detail including prevention oftrauma in the above age group. The second, practical part, analysis result of research. This part inc1udes anonyrnous questionnaire applied in tbe above age groups. Group oť respondents consists of parents of cbildren in early cbildhood and pre-school age as well. The practical part is followed by discussion. Powered by TCPDF (www.tcpdf.org)
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