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Hypermobility syndrome and its connection with nerve entrapment syndromes, the example of the thoracic outlet syndrome
Jiquelle, Carine ; Pavlů, Dagmar (advisor) ; Véle, František (referee)
ABSTRACT Background: Since its first mention by Kirk et al. in 1967 and its recognition as a full- fledged rheumatologic disorder, the hypermobility syndrome (HMS) has been increasingly investigated and reported in the scientific literature. Expeditiously renamed benign joint hypermobility syndrome in the patent absence of life-threatening complications, its relatively innocuous character has been progressively reconsidered. In fact, the HMS tends to date to be considered analogous to the Ehlers-Danlos syndrome-hypermobility type, a heritable disease of connective tissue, and therefore emerges as a chiefly rheumatologic disorder with possible widespread reverberations in practically all organs and systems. The condition thence goes beyond the sole involvement of the musculoskeletal system and is recurrently associated with seemingly-unrelated and more or less severe conditions (cardiovascular, pulmonary, gastro- intestinal…). However, neurologic implications of the hypermobility syndrome remain poorly documented, particularly those regarding the peripheral nervous system. Ranking amongst the afflictions of the latter, nerve entrapment syndromes (NES) comprehend a multitude of categories, notably the thoracic outlet syndrome (TOS). And if their pathological mechanisms are generally apprehended...
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Hypermobility syndrome and its connection with nerve entrapment syndromes, the example of the thoracic outlet syndrome
Jiquelle, Carine ; Pavlů, Dagmar (advisor) ; Véle, František (referee)
ABSTRACT Background: Since its first mention by Kirk et al. in 1967 and its recognition as a full- fledged rheumatologic disorder, the hypermobility syndrome (HMS) has been increasingly investigated and reported in the scientific literature. Expeditiously renamed benign joint hypermobility syndrome in the patent absence of life-threatening complications, its relatively innocuous character has been progressively reconsidered. In fact, the HMS tends to date to be considered analogous to the Ehlers-Danlos syndrome-hypermobility type, a heritable disease of connective tissue, and therefore emerges as a chiefly rheumatologic disorder with possible widespread reverberations in practically all organs and systems. The condition thence goes beyond the sole involvement of the musculoskeletal system and is recurrently associated with seemingly-unrelated and more or less severe conditions (cardiovascular, pulmonary, gastro- intestinal…). However, neurologic implications of the hypermobility syndrome remain poorly documented, particularly those regarding the peripheral nervous system. Ranking amongst the afflictions of the latter, nerve entrapment syndromes (NES) comprehend a multitude of categories, notably the thoracic outlet syndrome (TOS). And if their pathological mechanisms are generally apprehended...
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