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Effect of illusory movements physiotherapy on vital and metabolic functions of patients with large burns
Jelínková, Pavla ; Bakalář, Bohumil (advisor) ; Jevič, Filip (referee) ; Smetana, Jiří (referee)
Name and surname of the author: Bc. Pavla Jelínková Institution: Third Faculty of Medicine, Charles University Title: Effect of illusory movements physiotherapy on vital and metabolic functions of patients with large burns Supervisor: MUDr. Bohumil Bakalář Year of defense: 2022 Keywords: large burns; illusory movements; proprioceptive neuromuscular facilitation; vital functions; catabolism; intensive care unit-acquired weakness The aim of this thesis was to determine how the usage of functional proprioceptive stimulation (so-called illusory movements) influenced vital and metabolic functions of patients with extensive burns. In the first part of the thesis we focus on defining the issues we encounter in patients with extensive trauma. Extensive damage not only affects metabolic and vital functions, but the extent of the skin injury changes prognosis of the injured person and the length of hospitalization. The longer patients are hospitalized in intensive care units, the more we encounter acquired muscle weakness. One of the ways to prevent this phenomenon is effective rehabilitation, which is quite challenging in burn patients. As an alternative, the usage of proprioceptive stimulation is offered. It creates illusions instead of real movements in the cerebral cortex. However, there has been no...
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Life quality of patients with the diagnosis myasthenia gravis
Jelínková, Pavla ; Mareš, Jiří (advisor) ; Gigalová, Veronika (referee)
Name and surname of the author: Pavla Jelínková Institution: Charles University Faculty of Medicine in Hradec Králové, Department of Social Medicine, Department of Nursing Title: Life quality of patients with the diagnosis Myasthenia Gravis Supervisor: prof. PhDr. Jiří Mareš, CSc. Number of pages: 82 Number of attachments: 6 Year: 2020 Keywords: Quality of life, Myasthenia gravis, neuromuscular transmission, score, autoimmune diseases, nursing care The Myasthenia gravis (MG) is a neuromuscular disease, which evolves due to the damages of moto units (motorneurons in the ventral root of spinal nerve, peripheral nerves, neuromuscular junctions, muscles). The MG is a chronic disease of the peripheral nervous system. The thesis deals with nursing care of the patients with the diagnosis Myasthenia gravis. The first part describes the disease, its diagnostics and cure in the past and nowadays and the nursing and rehabilitation care of Myasthenia gravis patients. The empirical part analyses the current quality of life of patients with disease Myasthenia gravis by using questionnaire MG- QOL-15. The empirical part of the thesis analyses the current quality of life of patients with the disease Myasthenia gravis. The research IS comprised of the questionnaire MG-QOL-15 and its analysis by the NCSS programme...
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Histone code and its regulation during early embryonic development in pigs
Jelínková, Pavla ; Žalmanová, Tereza (advisor) ; Miriama, Miriama (referee)
Both pronuclei of the zygote undergo epigenetic changes after fertilization, which determines the quality of the zygote and successful early mammalian embryonic development. Shortly after fertilization epigenetic asymmetry among the pronuclei of the zygote is evident, while the paternal pronucleus undergoes active DNA demethylation, the DNA of the maternal pronucleus remains methylated. The male pronucleus in addition undergoes histone acetylation, whereas the histones of the female pronucleus remain methylated. Asymmetry of pronuclei and their epigenetic status predicts successful reprogramming of the genome, and thus the success of embryonic development. For the successful development of the embryo is therefore required correct formation of both of these pronuclei of the zygote and this formation of pronuclei is regulated by post-translational histone modifications called histone code. It was hypothesized that the histone code is regulated by the activity of NADP+ - dependent histone deacetylases, sirtuins.
In the experiment were used fully grown in vitro maturated pig oocytes that were fertilized with pig spermatozoa in vitro. After isolation of zygotes cultured with addition of the activator sirtuin resveratrol was performed immunofluorescence analysis of acetylated and methylated histone H3 at lysine K9 of pronuclei of the zygotes. From the results of control group asymmetry between the pronuclei of the zygote is evident; wherein the male pronucleus exhibits higher acetylation intensity contrast female pronucleus exhibits higher methylation intensity. After adding resveratrol to all experimental groups female pronucleus showed a significant increase of the methylated histone H3 at lysine K9, and contrary to the male pronucleus significant decrease of acetylated histone H3 at lysine K9.
Sirtuins are involved in the regulation of histone code in porcine zygote and it can be assumed that they also play a role during subsequent embryonic development, which is the subject of further study.
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The drugs problem in the member states of the European Union
JELÍNKOVÁ, Pavla
Annotation This bachelor thesis entitled " The drugs problem in the member states of the European Union" investigates actual and global problem of drugs. Its main aim is to present information about the EU work, its decisions and solutions adopted at the EU level. The first of the four parts of my work defines some basic notions related to the theme. The second part depicts problems connected with using drugs (for example drug production and trafficking). Another part of this work describes actual drug situation in the EU and its member states, which is based on Annual report 2007 on the state of the drugs problem in Europe published by EMCDDA. The last part of my bachelor thesis mentions main approaches to the drug problem, principles and objectives of the EU Drugs Strategy for the period 2005-2012 and some important organisations that cooperate with the EU on the fight against drugs.
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