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Notice in the French employment law compared with the employment law in the Czech republic
Jakubec, Martin ; Morávek, Jakub (advisor) ; Koldinská, Kristina (referee)
Abrégé Cette memoire a pour le but la présentation de la demission et le licenciement dans le droit du travail français et la comparaison de ceux-ci avec le droit du travail tchèque. La partie préliminaire présente en bref le code du travail français et explique aussi le statut du salarié et de l'employeur dans le droit français et mentionne des problèmes qui s'attachent à cette problématique. La partie préliminaire, qui parle du caractère élémentaire de la relation de travail est suivie par la seconde partie, la partie principale, qui disserte sur des conditions dans lesquelles la relation de travail peut être rompue dans le droit français et compare leurs différences avec le droit tchèque. A la fin l'auteur délibère sur ceux différences et leurs avantages et désavantages.
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Regulatory mechanisms of CD47 surface expression
Jakubec, Martin ; Drbal, Karel (advisor) ; Dibus, Michal (referee)
CD47 glycoprotein can be found on the surface of all healthy cells in our body. The interaction of CD47 with inhibitory receptor SIRPα on the macrophage leads to the inhibition of phagocytosis. This makes CD47 irreplaceable for the safe recognition of own cells and removal of aged or apoptotic cells. Apart from this, CD47 plays a major role in several essential signalling pathways, such as cell adhesion and motility or calcium homeostasis. The level of CD47 expression and its presence on the cell membrane depends not only on the type of tissue, but also on the age of a cell. An increased expression of CD47 protein has also been observed in the cells undergoing tumorigenic transformation, allowing them to escape from tumour immunosurveillance. Spontaneous regulation of the CD47 gene expression is achieved via regulatory transcription factors, such as NF-κB or HIF-1. Another mechanism of CD47 regulation includes the 3'UTR of CD47 mRNA, which serves as a binding site for either regulatory proteins, such as HuR, or miRNAs. CD47 expression can thus be regulated on both transcriptional, as well as translational level. However, appropriate topological CD47 localization within the cell and on the cell surface has also an important effect of its physiological function. Our in depth understanding of key regulatory...
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Role of enteric alpha-defensins in inflammatory bowel disease
Jakubec, Martin ; Filipp, Dominik (advisor) ; Krulová, Magdaléna (referee)
Human intestine represents an essential immune organ that creates the largest interface between our immune system and microbiota from the environment. Considerable parts of the intestine are often severely damaged during Crohn's disease (CD), chronic inflammatory condition with a rising incidence in the western countries. Outbreak of intestinal inflammation is associated with the loss of intestinal homeostasis, co-manifested as a microbial dysbiosis. It is yet unknown whether this bacterial dysbiosis is the cause of intestinal inflammation, or rather it's consequence. In healthy individuals, the homeostatic relationship is greatly influenced by Paneth cells (PC). These cells produce and secrete a wide variety of antimicrobial proteins and peptides, such as enteric α-defensins, that constantly shape the composition of intestinal microbiota. Unsurprisingly, defects in PC's functioning have been linked to the development of CD. Here, we build on our previously published data which showed that a defect in immune central tolerance is the cause of PC depletion. Due to phenotypic and functional resemblance, we hypothesized that such depletion of PCs could constitute a trigger for the development of CD in at least a subset of these patients. This thesis represents a case control study of newly diagnosed...
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Photochemical Derivatization of Helicenes.
Jakubec, Martin
Helicenes are a class of polyaromatic compounds that have been increasingly studied over the past years. Their chirality, extended π-system and other intriguing characteristics make them worth exploiting in various fields of chemistry and material science.
Fulltext: content.csg -  PDF
Plný tet: SKMBT_C22019053108330 - PDF
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Photochemical Derivatization of Helicenes.
Jakubec, Martin ; Ghosh, I. ; Storch, Jan ; König, B.
This work is focused on the use of simple helicene derivatives as substrates for modern photochemical methods. Halogen containing substrates are transformed in the reductive pathway to helicenyl radicals, before being trapped by different radical traps. In the oxidative pathway, activated alkoxyhelicenes undergo photoredox catalyzed reactions, yielding various carbon-carbon, as well as carbon-heteroatom containing compounds.\n
Fulltext: content.csg - PDF
Plný tet: SKMBT_C22018110615051 - PDF
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Regulatory mechanisms of CD47 surface expression
Jakubec, Martin ; Drbal, Karel (advisor) ; Dibus, Michal (referee)
CD47 glycoprotein can be found on the surface of all healthy cells in our body. The interaction of CD47 with inhibitory receptor SIRPα on the macrophage leads to the inhibition of phagocytosis. This makes CD47 irreplaceable for the safe recognition of own cells and removal of aged or apoptotic cells. Apart from this, CD47 plays a major role in several essential signalling pathways, such as cell adhesion and motility or calcium homeostasis. The level of CD47 expression and its presence on the cell membrane depends not only on the type of tissue, but also on the age of a cell. An increased expression of CD47 protein has also been observed in the cells undergoing tumorigenic transformation, allowing them to escape from tumour immunosurveillance. Spontaneous regulation of the CD47 gene expression is achieved via regulatory transcription factors, such as NF-κB or HIF-1. Another mechanism of CD47 regulation includes the 3'UTR of CD47 mRNA, which serves as a binding site for either regulatory proteins, such as HuR, or miRNAs. CD47 expression can thus be regulated on both transcriptional, as well as translational level. However, appropriate topological CD47 localization within the cell and on the cell surface has also an important effect of its physiological function. Our in depth understanding of key regulatory...
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