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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
název v anglickém jazyce není uveden
 Housa, Daniel ; Vernerová, Zdeňka (advisor) ; Dostálová, Ivana (referee) ; Ehrmann, Jiří (referee)
Adipocytokines are a group of adipose tissue-derived cytokines that have been discovered since early nineties. The role of selected adipocytokines in the prostate carcinoma and in selected joint diseases was evaluated. In the first part of this work the role of adiponectin and resistin in the prostate cancer development and progression was examined. Immunohistochemical expression and serum levels of these adipocytokines were evaluated in both groups of patients with benign prostate hyperplasia and prostate cancer of pathological grade pT2 and pT3, respectively. Moreover, selected metabolic, biochemical and anthropometric parameters were included into this study. Serum adiponectin levels did not differ between prostate benign hyperplasia and prostate cancer generally, but they were significantly higher in pT3 in comparison to pT2 group. In agreement with the results of serum levels, tissue immunohistochemistry showed enhanced staining intensity of adiponectin in neoplastic glands and to a lesser degree in prostatic intraepithelial neoplasia while within benign prostate hyperplasia the immunohistochemical staining was generally low. None relation of adiponectin expression to disease grade or stage was observed. In resistin no difference between benign hyperplasia and prostate cancer in respect to serum levels...
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Adipose tissue and its role in development of insulin resistance and systemic inflammatory reaction
 Roubíček, Tomáš ; Haluzík, Martin (advisor) ; Stárka, Luboslav (referee) ; Housa, Daniel (referee)
Hyperglycemia and insulin resistance are tightly interconnected pathophysiological conditions that increase the risk for development of cardiovascular diseases. Our current knowledge indicates that one of important reasons leading to the development of insulin resistance could lies in a dysfunction of adipose tissue with subsequent ectopic lipids accumulation in muscles and liver. Adipose tissue represents the main body storage site of energy. Furthermore, adipose tissue is also an active endocrine organ producing numerous biologically active molecules, e.g. cytokines, proinflammatory or to a lesser degree anti-inflammatory factors or components of the renin-angiotensin-aldosterone system. Some of the components of the local renin-angiotensin-aldosterone system produced by the adipose tissue can directly induce local insulin resistance within the adipose tissue. Hyperglycemia and insulin resistance are also common in critically ill patients and exaggeration of insulin resistance in these patients is accompanied by increased morbidity and mortality. Our previous study has demonstrated that adipose tissue plays an important role in the development of hyperglycemia and insulin resistance in critically ill patients by production of numerous proinflammatory cytokines. First part of this dissertation thesis is...
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1 Housa, D.
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