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Behavioral disorders in children and adolescents in a children's home
Homolová, Zuzana ; Komárková, Tereza (advisor) ; Klapálková, Veronika (referee)
This thesis deals with the manifestations of behavioural disorders in children and adolescents placed in a selected children's home. The thesis consists of a theoretical and an empirical part. The theoretical part defines the basic concepts in the field of foster care, describes the most common childhood behavioural disorders and their manifestations, the risks of behavioural disorders. Subsequently, the thesis defines the possibilities to intervene and support children and adolescents with behavioural disorders. The empirical part is dedicated to research investigation in a specific children's home. The data was obtained using semi-structured interviews with five respondents who were educators in the orphanage and via documentation of the children, then it was processed using the thematic analysis method. More specifically, I used inductive approach, which I further worked with in open coding. The aim of the thesis was to identify the manifestations of behavioural disorders in the children in a chosen orphanage. Another goal of the thesis was to identify which forms of intervention are applied in the selected children's home. The research has shown that children and adolescents with behavioural disorders most commonly exhibit prolonged and recurrent absent-mindedness, violent episodes, short...
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Palliative care and its possibilities in residential services for seniors
HOMOLOVÁ, Zuzana
The bachelor thesis is focused on the prospects of providing general palliative care in residential services for the elderly. The objective of the bachelor's thesis is to find out what principles are applied by workers in residential services for the elderly when providing general palliative care. The issue of palliative care is very topical, as the aging of the population is an increasingly visible phenomenon of our society due to low birth rates and longer life expectancy.
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Verapamil determination using sequential injection analysis with chemiluminescence detection
Homolová, Zuzana ; Sklenářová, Hana (advisor) ; Šatínský, Dalibor (referee)
The verapamil was determined by the technique of sequential injection analysis (SIA) with chemiluminescence (CL) detection. The CL was emitted during the oxidation of the analyte by permanganate in aqueous sulphuric acid in the presence of CL enhancer polyphosphate (PFS). Concentration, order, volume of reagents and flow rate were optimised. Also influence of solvents 60% methanol and 60% ethanol was proved. The optimum order, volumes and concentrations of reagents for aqueous solution of verapamil were: 30 μl of 10 mM KMnO4, 50 μl of 2% PFS, 50 μl of 1 mM verapamil, 30 μl of 1 M H2SO4 and for 60% ethanolic solution of verapamil were: 20 μl of 10 mM KMnO4, 30 μl of 2% PFS, 50 μl of 1 mM verapamil, 30 μl of 2 M H2SO4, 30 μl of 2% PFS and 30 μl/s flow rate. The transient CL signal was recorded at the wavelength 390 nm. Calibration curves relating the intensity of CL (peak heights) to the concentration of the analyte were curvilinear with rectilinear sections in the range 510-5 - 510-3 M for aqueous solution and 110-5 - 110-3 M for 60% ethanolic solution of verapamil. The limits of detection were 210-5 M for aqueous solution and 110-5 M for 60% ethanolic solution. Repeatability of peak heights (RSD, n = 10) ranged between 4.43 % (110-4 M) and 1.83 % (110-3 M) for aqueous solution, and...
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Chemiluminescence determination of propylgallate using the flow injection analysis
Homolová, Zuzana ; Dolejšová, Jana (advisor) ; Sklenářová, Hana (referee)
7 Summary The literature was searched for articles dealling with various ways of determining propylgallate and articles concerning the possible use of the FIA method with chemiluminescent detection in pharmaceutical analysis. Measurement conditions were optimized. Appropriate device parameters, time and flow rate were set. The optimum composition of the carrier stream was found and the influence of some substances to enhance chemiluminescence was tested. The effect on increasing the intensity of CL was detected for sodium polyphosphate, which increased 2.3-fold CL intensity. Under optimum conditions the calibration curve was measured without addition of PFS and the results were evaluated. Measurement conditions have been modified and calibration curve with the addition of PFS was evaluated. Using the calibration curve with the addition of PFS the substance of propylgallate (Aldrich Company) and pharmaceutical formulation were analyzed. Comparative method was chosen - Chelatometric titration. Also, using this method the substance propylgallate (Aldrich company) and formulation were assayed. The results obtained by FIA with chemiluminescent detection and chelatometric titration were statistically evaluated using Student's test and Moore's t test and thus their comparability was demostrated.
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Verapamil determination using sequential injection analysis with chemiluminescence detection
Homolová, Zuzana ; Sklenářová, Hana (advisor) ; Šatínský, Dalibor (referee)
The verapamil was determined by the technique of sequential injection analysis (SIA) with chemiluminescence (CL) detection. The CL was emitted during the oxidation of the analyte by permanganate in aqueous sulphuric acid in the presence of CL enhancer polyphosphate (PFS). Concentration, order, volume of reagents and flow rate were optimised. Also influence of solvents 60% methanol and 60% ethanol was proved. The optimum order, volumes and concentrations of reagents for aqueous solution of verapamil were: 30 μl of 10 mM KMnO4, 50 μl of 2% PFS, 50 μl of 1 mM verapamil, 30 μl of 1 M H2SO4 and for 60% ethanolic solution of verapamil were: 20 μl of 10 mM KMnO4, 30 μl of 2% PFS, 50 μl of 1 mM verapamil, 30 μl of 2 M H2SO4, 30 μl of 2% PFS and 30 μl/s flow rate. The transient CL signal was recorded at the wavelength 390 nm. Calibration curves relating the intensity of CL (peak heights) to the concentration of the analyte were curvilinear with rectilinear sections in the range 510-5 - 510-3 M for aqueous solution and 110-5 - 110-3 M for 60% ethanolic solution of verapamil. The limits of detection were 210-5 M for aqueous solution and 110-5 M for 60% ethanolic solution. Repeatability of peak heights (RSD, n = 10) ranged between 4.43 % (110-4 M) and 1.83 % (110-3 M) for aqueous solution, and...
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Chemiluminescence determination of propylgallate using the flow injection analysis
Homolová, Zuzana ; Dolejšová, Jana (advisor) ; Sklenářová, Hana (referee)
7 Summary The literature was searched for articles dealling with various ways of determining propylgallate and articles concerning the possible use of the FIA method with chemiluminescent detection in pharmaceutical analysis. Measurement conditions were optimized. Appropriate device parameters, time and flow rate were set. The optimum composition of the carrier stream was found and the influence of some substances to enhance chemiluminescence was tested. The effect on increasing the intensity of CL was detected for sodium polyphosphate, which increased 2.3-fold CL intensity. Under optimum conditions the calibration curve was measured without addition of PFS and the results were evaluated. Measurement conditions have been modified and calibration curve with the addition of PFS was evaluated. Using the calibration curve with the addition of PFS the substance of propylgallate (Aldrich Company) and pharmaceutical formulation were analyzed. Comparative method was chosen - Chelatometric titration. Also, using this method the substance propylgallate (Aldrich company) and formulation were assayed. The results obtained by FIA with chemiluminescent detection and chelatometric titration were statistically evaluated using Student's test and Moore's t test and thus their comparability was demostrated.
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