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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
The relation between latent toxoplasmosis and schizophrenia
 Sglundová, Markéta ; Flegr, Jaroslav (advisor) ; Holub, David (referee)
The relation between the intracellular parasite Toxoplasma gondii and schizophrenia was studied and confirmed in several studies. There are proofs that latent toxoplasmosis deteriorates the course of schizophrenia. The goal of this study was to clarify whether there are differences between subjectively perceived quality of life of infected and non-infected psychiatric patients. We tested men and women from the PCP treated for the diagnosis of schizophrenia, who undertook serology blood tests for detection of anamnestic T. gondii antibodies. Patients also filled out two questionaires that assessed subjectively perceived quality of life - SOS-10 and WHOQOL-BREF. Patients filled out these questionaires twice, both at the start of the study before coming to psychiatric therapeutical institution and after one year. During the first testing were the questionaires filled out by 171 persons, after one year by 108 persons. Based on the results of these tests we found out that latent toxoplasmosis had a negative impact on subjectively perceived quality of life of schizophrenia patients, particularly on infected women. On the other hand, the quality of life of non-infected patients improved during one year. The effect of toxoplasmosis on quality of life was gender related, which could be explained by already...
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Latent toxoplasmosis as a risk factor for the development of schizophrenia and a modulator of its course
 Holub, David ; Libiger, Jan (advisor) ; Přikryl, Radovan (referee) ; Pavlovský, Pavel (referee)
Schizophrenia is serious, multifactorial and chronic disease. The crucial tasks to introduce effective preventive, diagnostic and treatment measures is to identify etiology factors, their interaction and etiology factors-genetic predispositon interactions. TG (Toxoplasma gondii) is the most promising infectious candidate with "schizophrenogenic" potential. Toxoplasmosis is a lifelong parasitosis considered as a risk factor to schizophrenia. No consistent clinical pattern has been detected in Toxoplasma-infected schizophrenia patients as yet. We assessed symptom profile, cognitive performance and treatment response of Toxoplasma- infected and Toxoplasma-free schizophrenia patients to determine whether co-occurrence of schizophrenia and Toxoplasma infection modifies clinical presentation and the course of schizophrenia. We screened for anti-Toxoplasma antibodies in 251 patients with schizophrenia spectrum disorder consecutively admitted to Prague Psychiatric Centre between 2000 and 2010. Fifty-seven patients were infected (22.7%). Infected patients spent more days in hospital during their last admission compared to uninfected ones (p=0,003; mean difference 32.9 days). Schizophrenia started approximately one year earlier in infected men and about 3 years later in infected women. This corresponds to sex related...
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See also: similar author names
4 Holub, Daniel
4 Holub, Dominik
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