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The Sinitic Nexus: Becoming Asian in the Chinese-language Literature of Manchuria under Japanese Rule
Blahota, Martin ; Lomová, Olga (advisor) ; Smith, Norman (referee) ; Hladíková, Kamila (referee)
The Sinitic Nexus: Becoming Asian in the Chinese-language Literature of Manchuria under Japanese Rule Abstract This dissertation analyzes modern Chinese-language literature produced in Manchuria under Japanese rule during the 1930s and 1940s. The protagonists in this literature identify not only with Manchuria, China, and Japan but also with East Asia. In my readings, a sense of belonging to China or East Asia, but more often to the latter, is one of the main sources for the cultural identities of these protagonists. In this study, I conceptualize the identities represented in the Chinese-language literature of Manchuria as a complex combination of entangled identities that I call the "Sinitic nexus." I argue that the "Asian" element of this nexus of identities is constructed by Asianism, or the pan-national discourse of "Asia." While thus far, the significance of "Asian" identities in the Chinese-language literature of Manchuria has been overlooked both in scholarship on this literature and in the intellectual history of Asianism, I focus on it to reveal the complexity of this literature from a fresh perspective that goes beyond naturalized categories such as nation and the dichotomy of the colonizer and the colonized, and also to show how Asianist thought was creatively reproduced in literature through...
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Impact of pattern and functional properties of tumor-infiltrating immune cells for clinical outcome of head and neck cancer
Hladíková, Kamila ; Špíšek, Radek (advisor) ; Plzák, Jan (referee) ; Reiniš, Milan (referee)
Head and neck squamous cell carcinoma encompasses a complex and heterogeneous group of malignant diseases. Originally, this tumor type was associated with tobacco and alcohol consumption. However, a significantly expanding subset of tumors associated with oncogenic human papillomavirus infection arising in deep tonsillar crypts was identified within the last decades. Due to the essential role of the immune system in antiviral and anticancer immune response, the prognosis of patients is significantly influenced by the volume, composition and functional capacity of the immune infiltrate. The immunosuppressive landscape of head and neck cancer leads to unfavorable outcome of patients and decreased efficacy of immunotherapy. The response rate to standard treatment is high, however, standard therapy is accompanied by considerable toxicity influencing the quality of life. In 2016, the first immunotherapeutics for the treatment of patients with recurrent squamous cell carcinoma of the head and neck were approved - the anti-PD-1 immune checkpoint inhibitors nivolumab and pembrolizumab. This type of therapy, based on mitigation of immunosuppression, shows strong efficacy and less toxicity in combination with other therapies. Therefore, anti-PD-1 immunotherapy was recently approved in the first-line...
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Impact of pattern and functional properties of tumor-infiltrating immune cells for clinical outcome of head and neck cancer
Hladíková, Kamila
Head and neck squamous cell carcinoma encompasses a complex and heterogeneous group of malignant diseases. Originally, this tumor type was associated with tobacco and alcohol consumption. However, a significantly expanding subset of tumors associated with oncogenic human papillomavirus infection arising in deep tonsillar crypts was identified within the last decades. Due to the essential role of the immune system in antiviral and anticancer immune response, the prognosis of patients is significantly influenced by the volume, composition and functional capacity of the immune infiltrate. The immunosuppressive landscape of head and neck cancer leads to unfavorable outcome of patients and decreased efficacy of immunotherapy. The response rate to standard treatment is high, however, standard therapy is accompanied by considerable toxicity influencing the quality of life. In 2016, the first immunotherapeutics for the treatment of patients with recurrent squamous cell carcinoma of the head and neck were approved - the anti-PD-1 immune checkpoint inhibitors nivolumab and pembrolizumab. This type of therapy, based on mitigation of immunosuppression, shows strong efficacy and less toxicity in combination with other therapies. Therefore, anti-PD-1 immunotherapy was recently approved in the first-line...
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Impact of pattern and functional properties of tumor-infiltrating immune cells for clinical outcome of head and neck cancer
Hladíková, Kamila ; Špíšek, Radek (advisor) ; Plzák, Jan (referee) ; Reiniš, Milan (referee)
Head and neck squamous cell carcinoma encompasses a complex and heterogeneous group of malignant diseases. Originally, this tumor type was associated with tobacco and alcohol consumption. However, a significantly expanding subset of tumors associated with oncogenic human papillomavirus infection arising in deep tonsillar crypts was identified within the last decades. Due to the essential role of the immune system in antiviral and anticancer immune response, the prognosis of patients is significantly influenced by the volume, composition and functional capacity of the immune infiltrate. The immunosuppressive landscape of head and neck cancer leads to unfavorable outcome of patients and decreased efficacy of immunotherapy. The response rate to standard treatment is high, however, standard therapy is accompanied by considerable toxicity influencing the quality of life. In 2016, the first immunotherapeutics for the treatment of patients with recurrent squamous cell carcinoma of the head and neck were approved - the anti-PD-1 immune checkpoint inhibitors nivolumab and pembrolizumab. This type of therapy, based on mitigation of immunosuppression, shows strong efficacy and less toxicity in combination with other therapies. Therefore, anti-PD-1 immunotherapy was recently approved in the first-line...
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Multilayered Subversion and Double-edged Subjectivity: Chinese Avant-garde Literature of the Second Half of the 1980s
Reismüller, František ; Lomová, Olga (advisor) ; Hladíková, Kamila (referee) ; Mittler, Barbara (referee)
Univerzita Karlova Filozofická Fakulta Ústav Dálného východu Teorie a dějiny literatur zemí Asie a Afriky Disertační Práce Mgr. František Reismüller Vedoucí práce: Prof. PhDr. Olga Lomová, CSc. 2019 Multilayered Subversion and Double-edged Subjectivity: Chinese Avant-garde Literature of the Second Half of the 1980s Abstract This thesis analyzes Chinese avant-garde literature of the second half of the 1980s in order to identify the main literary features that are common for the otherwise very diverse works of this literary current. First part of the thesis describes literary-political conditions, discursive changes and literary-theoretical discussions between 1978 and 1989 related to the rapid development of Chinese literature of that period and relevant for the following analysis. Second part then analyzes works of selected authors of the Chinese avant-garde literature and using Western literary theory in combination with the theoretical background described in the first part of the thesis it identifies the most important characteristics of the given literary current. The thesis then reaches the conclusion that the works of the Chinese avant-garde literature of the second half of the 1980s show a critical amount of common features, such as subversion, metafictional elements or questioning of the...
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The exotic other and negotiation of Tibetian self: a study of modern Tibetian fiction of the 1980s
Hladíková, Kamila ; Andrš, Dušan (advisor) ; Kolmaš, Josef (referee) ; Maconi, Lara (referee) ; Slobodník, Martin (referee)
(ENGLISH) Proposed dissertation examines a so-far less discussed topic of modern Tibetan literature, which is for the purpose of this study defined ethnically, not as based on language of literary creation. Because of specific socio-historical and cultural conditions, modern literature in the Western sense has not emerged in Tibet until the second half of the 20th century. The emergence of modern Tibetan literature was, as in case of genesis of other Asian modern-style literatures, initiated by an encounter with another culture (i.e. 'Western', 'rational', 'scientific' worldview, which was in case of Tibet introduced through the communist China). In the beginning of the 1980s, this process was de facto enforced by the need (of Chinese as well as Tibetan elites) to establish this literature as an authentic Tibetan voice, affirming their will to modernization through Tibet's belonging to the PRC. At the same time, modern Tibetan literature emerged in a period of certain liberalization after the Cultural Revolution, which in Tibet manifested as a kind of 'national revival', oriented specifically on restoration of religion and related cultural heritage. During that period this literature thus served two seemingly contradictory interests. In Tibetan society it played mainly enlightening and didactic...
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