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Influence of autism on facial morphology
Cenková, Klára ; Velemínská, Jana (advisor) ; Harnádková, Katarína (referee)
Autism (ASD) is a severe pervasive neurodevelopmental disorder with an as yet unclear etiology but increasing incidence. Early diagnosis and early initiation of therapy are crucial to the success of its treatment and to improving the quality of life of individuals with PAS. The identification of biomarkers in the form of specific facial features of individuals with autism can contribute significantly to facilitating diagnosis. These facial dysmorphologies have their basis in the prenatal period as a consequence of the common and interacting embryogenesis of the face and brain and reflect the neurodevelopmental basis of autism. Using special anthropometric methods, specific facial phenotypes can be determined, which can also be used to classify individuals with PAS into groups according to the severity of the disorder. Key words: Autism, facial dysmorphology, ASD, biomarkers, anthropometry
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Bioarchaeology of the plague epidemics of medieval Europe of the first millennium: history and molecular-biological knowledge
Polakovičová, Nicol ; Brůžek, Jaroslav (advisor) ; Harnádková, Katarína (referee)
This paper outlines the first documented pandemic, Justinianic plague, which emerged in sixth century A. D. It contains basic overview of the disease, it's symptoms, life cycle and possible hosts and transmitters. Next, it focuses on the causative agent of the plague - bacterium Yersinia pestis, it's genome and evolution. The thesis comes to conclusion that the plague accompanies humanity from as early as late neolithic period. For full overview, the paper also contains information on first epidemics of our era - three epidemics, whose names consist of word "plague", although they are not plagues. The paper looks at the first real plague from several angles - it analyses literary sources, tries to find evidence in art, andlast but not least, it looks at recent bioarchaeological research. Outlining of the ongoing debate on severity of the first pandemic is a key part of this thesis.
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