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Preparation of 3-phenylpentanoic and 3-phenylpent-2-enoic acid derivatives
Fatka, David ; Machara, Aleš (advisor) ; Veselý, Jan (referee)
This Bachelor's thesis deals with preparation of the intermediates of the analgesic tapentadol. The chosen synthetic strategy requires a preparation of appropriate derivatives of 3-phenylpentanoic and 3-phenylpent-2-enoic acid. Synthesis of those derivatives represents the cornerstone of the thesis. In the first part, the thesis describes an effort associated with a preparation of 1-[(3-benzyloxy)phenyl]propan-1-one, a necessary intermediate for the preparation of the titled compounds. Then addition reactions were studied on the aforementioned ketone. The second part of the thesis focuses on one particular addition, a Reformatsky reaction, and deals with further optimization. In addition, the submitted thesis also describes variety of attempts to carry out dehydration of the Reformatsky adducts, namely, benzylic tertiary alcohols. Powered by TCPDF (www.tcpdf.org)
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Chemical mistakes in the light of reality - identification and explanation
Fatka, David ; Šmejkal, Petr (advisor) ; Míka, Luděk (referee)
This thesis deals with widespread, chemically-themed misinformation. The the- oretical part describes psychological effects leading to myth spreading. It also descri- bes the debunking possibilities of such myths and the didactic reasons for misinformation- based work on the high school level. General practical part uses methods of content analysis upon random sample of School educational programmes to prove the usability of misinformation-based work in education. It also summarizes the organisations and resources useful for myth debunking. Specific practical part deals with analysis of chosen suspicious information, their credibility and the possibilities of educational work based on them. The chosen in- formation was the "medicinal" usage of chlorine dioxide solution. Rumors of alkaline diet and alleged harmfulness of aspartame, an artificial sweetener, were also chosen. The way they tend to be presented, none of these claims are backed. In all these cases, multiple unsubstantiated claims were found among proponents of these ideas.
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Preparation of 3-phenylpentanoic and 3-phenylpent-2-enoic acid derivatives
Fatka, David ; Machara, Aleš (advisor) ; Veselý, Jan (referee)
This Bachelor's thesis deals with preparation of the intermediates of the analgesic tapentadol. The chosen synthetic strategy requires a preparation of appropriate derivatives of 3-phenylpentanoic and 3-phenylpent-2-enoic acid. Synthesis of those derivatives represents the cornerstone of the thesis. In the first part, the thesis describes an effort associated with a preparation of 1-[(3-benzyloxy)phenyl]propan-1-one, a necessary intermediate for the preparation of the titled compounds. Then addition reactions were studied on the aforementioned ketone. The second part of the thesis focuses on one particular addition, a Reformatsky reaction, and deals with further optimization. In addition, the submitted thesis also describes variety of attempts to carry out dehydration of the Reformatsky adducts, namely, benzylic tertiary alcohols. Powered by TCPDF (www.tcpdf.org)
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